Topic
Recurrent Angiosarcoma
About: Recurrent Angiosarcoma is a research topic. Over the lifetime, 25 publications have been published within this topic receiving 169 citations.
Papers
TL;DR: A 77-year-old male patient presented with a 2-year history of recurrent angiosarcoma of the face and scalp, and examination showed a flat, sharply defined, 30-cm duskyred plaque involving the left tragus and preauricular region, which was confirmed by histological analysis.
Abstract: A 77-year-old male patient presented with a 2-year history of recurrent angiosarcoma (AS) of the face and scalp. At the time of initial diagnosis, multifocal growth of the tumor was visible. On the left side of the scalp and forehead, several 1to 5-cm reddish-brown nodules were noticed, one of which was ulcerated and hemorrhagic. Another 5-cm plaquelike lesion was seen on the left cheek. The presumptive diagnosis of AS was confirmed by histological analysis. X-ray examination of skull and chest, magnetic resonance imaging of the neck, and abdominal ultrasound revealed no evidence of local or distant metastases. Due to the extent of the disease, radical surgery was not an appropriate option. It was thus decided to treat the AS by field electron beam therapy (cheek, 56 Gy; scalp and forehead, each 60 Gy; 2 Gy per fraction), leading to a complete response. Three months after electron beam therapy had been completed, a local recurrence developed in the nonirradiated frontoparietal region. Likewise, this area was successfully treated by field electron beam therapy (60 Gy; 2 Gy per fraction). Six months later, an apparent relapse of the tumor was observed in the electron beam–irradiated field (Figure 1). Examination showed a flat, sharply defined, 30-cm duskyred plaque involving the left tragus and preauricular region. Biopsy specimens taken from the cheek revealed typical histological findings of AS (Figure 2). No evidence of metastases in repeated staging procedures was observed.
31 citations
Journal Article•
TL;DR: A 70-year-old female developed recurrent disease following radiotherapy for primary inoperable breast cancer 5.5 years previously, and pathology revealed recurrent breast cancer, along with a second primary malignancy, a dermal angiosarcoma.
Abstract: A 70-year-old female developed recurrent disease following radiotherapy for primary inoperable breast cancer 5.5 years previously. Salvage mastectomy was performed. Pathology revealed recurrent breast cancer, along with a second primary malignancy, a dermal angiosarcoma. Radical excision of recurrent angiosarcoma failed. Irradiation combined with hyperthermia showed good palliation. The angiosarcoma's possible relation to the initial radiotherapy is discussed.
28 citations
TL;DR: Adjuvant chemotherapy of ovarian angiosarcoma with a combination of doxorubicin and ifosfamide appears effective and should be considered in women at risk of relapse who wish to conserve fertility.
27 citations
TL;DR: A case of primary angiosarcoma of the thyroid in a 48‐year‐old female, who presented with a rapidly enlarging neck mass associated with compressive symptoms, who succumbed to the disease 7 months after diagnosis.
Abstract: Angiosarcoma of the thyroid is a rare and aggressive primary malignant tumor of the thyroid originally reported in patients from the Swiss Alpine region. Diagnosis of this tumor rests mainly on characteristic histopathological features of a malignant vascular tumor supported by immunopositivity for vascular markers e.g., CD31, Factor VIII, and CD34. Its cytological features, however, are not well-defined. We describe a case of primary angiosarcoma of the thyroid in a 48-year-old female, who presented with a rapidly enlarging neck mass associated with compressive symptoms. She had a history of hypothyroidism. The initial fine needle aspiration cytology of the neck mass was negative. She then underwent left hemithyroidectomy. Histologically, the tumor showed poorly differentiated malignant cells with eccentrically-placed nuclei, prominent nucleoli, and intracytoplasmic vacuoles admixed with mixed inflammatory cells. These showed immunopositivity for CD31 but were negative for CD34, Factor VIII, CK5/6, EMA, TTF-1, Thyroglobulin, Calcitonin, Melan A, and Calretinin. A diagnosis of poorly differentiated malignant tumor consistent with angiosarcoma was made. The patient was treated with radiation therapy but developed recurrence of the tumor. Second aspiration cytology of the recurrent tumor yielded hypocellular smears containing singularly dispersed atypical cells having eccentrically-placed nuclei with prominent macronucleoli and intracytoplasmic vacuoles within a background of inflammatory cells, consistent with recurrent angiosarcoma. Chemotherapy was started but she succumbed to the disease 7 months after diagnosis. The cytological, histopathological, immunohistochemical findings, and the clinical course are discussed.
18 citations
TL;DR: The data suggest that adjuvant therapy with Velban appears to alter significantly the clinical course of angiosarcoma of the breast.
Abstract: The present study represents the first attempt of treating primary angiosarcoma of the breast with adjuvant vinblastine sulfate (Velban) resulting in long-term survival with no evidence of disease in two patients. The rationale for using Velban as adjuvant therapy was based primarily on a prior study where the intratumoral administration of Velban into a large fungating recurrent angiosarcoma lesion resulted in eradication of tumor and also on the recognized responses of Kaposi's sarcoma to intralesional or systemic Velban administration. Patients received Velban at a dose of 4 mg/week for 15 and 12 months postoperatively. Both patients remain disease free at 12 and 10 years, respectively. Our data suggest that adjuvant therapy with Velban appears to alter significantly the clinical course of angiosarcoma of the breast.
16 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 4 |
| 2020 | 1 |
| 2019 | 2 |
| 2017 | 2 |
| 2016 | 1 |
| 2015 | 3 |