Topic
Rectal Sarcoma
About: Rectal Sarcoma is a research topic. Over the lifetime, 8 publications have been published within this topic receiving 58 citations.
Papers
TL;DR: The aim of this paper is to evaluate the experience, with special emphasis on the failure pattern after surgical therapy alone or combined with postoperative radiotherapy, for colorectal sarcomas.
Abstract: Background and Objectives: Colorectal sarcomas (CRS) are rare and their treatment remains controversial, especially for those located in the rectum. The aim of this paper is to evaluate our experience, with special emphasis on the failure pattern after surgical therapy alone or combined with postoperative radiotherapy.
Materials and Methods
The medical records and histological slides of 13 CRS patients treated between 1986 and 1996 were reviewed retrospectively.
Results
The patients included eight males and five females, with a median age of 54 years; nine of their primary tumors were located in the rectum, and four in the colon. The histologies were leiomyosarcoma in nine cases and malignant fibrous histiocytoma in four cases. Surgical treatment consisted of anatomical colectomy (four); local excision (three); abdominoperineal resection (APR)(two); low anterior resection (LAR)(two); LAR en bloc with the prostate (one), and total pelvic exenteration (one). One operative death occurred. The median size of the tumors was 8 cm (range, 5–40). The tumors were graded as low, three, and high, ten. The median follow-up was 24 months. Eight patients in the overall group developed recurrences as follows: local, three; local and distant, three, and distant, two. Five out of nine patients with rectal sarcoma received adjuvant postoperative radiotherapy (PRT). Local recurrence occurred in 20% (1/5) of those who received PRT, and in 100% (3/3) of those who did not. The overall 5-year survival was 40%, and the 5-year survival for patients with low-grade tumors was 66%, as compared with 22% for those with high-grade tumors.
Conclusions
The patterns of failure in CRS are combined in both local and distant sites. However, our results suggest that in rectal sarcoma, the use of surgery + PRT may reduce the local recurrence rate; in selected patients, it may allow for anal sphincter preservation. J. Surg. Oncol. 1998;69:36–40. © 1998 Wiley-Liss, Inc.
23 citations
TL;DR: Conservative surgery followed by radiation therapy (brachytherapy with or without external beam radiation) may be an alternative to radical surgery with the goals of local control of the disease and rectal sphincter preservation in selected patients.
Abstract: Leiomyosarcoma of the rectum is rare. The standard treatment is abdominoperineal resection and, in the past, radiation therapy has been employed in the palliative setting only. The authors report two additional cases of this rare tumor and its treatment using sphincterpreserving surgery and radiation therapy. In selected patients, conservative surgery followed by radiation therapy (brachytherapy with or without external beam radiation) may be an alternative to radical surgery with the goals of local control of the disease and rectal sphincter preservation. However, more experience and longer follow-up are needed before this approach could be recommended routinely.
19 citations
8 citations
Journal Article•
8 citations
1 Jan 2000
TL;DR: Two patients, both male patients, treated at coloproctologic unit at the Hospital General de Mexico with history of rectal bleeding, weight loss and positive immunohistochemical examination are presented, with final diagnosis of leiomyosarcoma.
Abstract: Almost all colorectal sarcomas are leiomyosarcomas that arise from smooth muscle cells of the intestinal wall. Presenting symptoms and endoscopic findings may be nonspecific and require surgical exploration for diagnosis. Complete resection is possible in 50 to 60 percent of the cases. Metastases to the peritoneal cavity and liver are common. Only 10 to 20 percent of completely resected patients may be considered cured. Patients with low-grade tumors live significantly longer than those with high grade tumors. Despite disappointing cure rates, radical resection provides good palliation. Neither radiation therapy nor chemotherapy have any proven efficacy as adjuvant therapies. The roles of sphincter-saving resection and local excision for rectal sarcoma are unclear. Conventional treatment of the lesions in the rectum has been abdominoperineal resection. Segmental resection remains indicated in the colonic tumors. Local excision has a rational basis given by the low incidence of lymph node involvement in colorectal sarcomas, but most of the existing data suggest that recurrence rates after local excision of rectal sarcomas are high. We present two cases both male patients, treated at coloproctologic unit at the Hospital General de Mexico. They had history of rectal bleeding, weight loss and positive immunohistochemical examination, with final diagnosis of leiomyosarcoma. Abdominoperineal resection for rectal leiomyosarcoma and sigmoidectomy for sigmoid leiomyosarcoma were the surgical treatments.
6 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 1 |
| 2014 | 1 |
| 2000 | 1 |
| 1998 | 1 |
| 1990 | 1 |
| 1971 | 1 |