Topic
Reaper
About: Reaper is a research topic. Over the lifetime, 393 publications have been published within this topic receiving 8460 citations. The topic is also known as: reaping machine & self-rake reaper.
Papers published on a yearly basis
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Papers
TL;DR: The serine protease Omi/HtrA2 is identified as a second mammalian XIAP-binding protein with a Reaper-like motif, and this protease autoprocesses to form a protein with amino-terminal homology to Smac/DIABLO and Reaper family proteins.
599 citations
TL;DR: In vivo evidence is provided that the proteins encoded by reaper, hid and grim activate cell death by inhibiting the anti‐apoptotic activity of the Drosophila IAP1 (diap1) protein, providing strong in vivo evidence for a previously published model of cell death regulation in Drosophile.
Abstract: Induction of apoptosis in Drosophila requires the activity of three closely linked genes, reaper, hid and grim. Here we show that the proteins encoded by reaper, hid and grim activate cell death by inhibiting the anti-apoptotic activity of the Drosophila IAP1 (diap1) protein. In a genetic modifier screen, both loss-of-function and gain-of-function alleles in the endogenous diap1 gene were obtained, and the mutant proteins were functionally and biochemically characterized. Gain-of-function mutations in diap1 strongly suppressed reaper-, hid- and grim-induced apoptosis. Sequence analysis of these alleles revealed that they were caused by single amino acid changes in the baculovirus IAP repeat domains of diap1, a domain implicated in binding REAPER, HID and GRIM. Significantly, the corresponding mutant DIAP1 proteins displayed greatly reduced binding of REAPER, HID and GRIM, indicating that REAPER, HID and GRIM kill by forming a complex with DIAP1. These data provide strong in vivo evidence for a previously published model of cell death regulation in Drosophila.
492 citations
TL;DR: The Reaper's Garden: Death and Power in the World of Atlantic Slavery, by Vincent Brown, Cambridge, MA and London, Harvard University Press, 2008, xviii, 340 pp. as mentioned in this paper.
Abstract: The Reaper's Garden: Death and Power in the World of Atlantic Slavery, by Vincent Brown, Cambridge, MA and London, Harvard University Press, 2008, xviii, 340 pp. $35.00. ISBN 13: 978-0-674-02422-9,...
337 citations
TL;DR: A novel Drosophila gene, dredd, is identified, which shares extensive homology to all members of the caspase gene family, and expression of REAPER, GRIM, and HID was found to trigger processing of DREDD protein precursor through a mechanism that is insensitive to, and upstream of, known caspases.
275 citations
TL;DR: The data indicate that caspase activation and apoptosis in Drosophila are independently controlled by at least two distinct regulatory pathways that converge at the level of caspases activation.
214 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 1 |
| 2020 | 5 |
| 2019 | 8 |
| 2018 | 7 |
| 2017 | 9 |
| 2016 | 4 |