Topic
Rabbitpox
About: Rabbitpox is a research topic. Over the lifetime, 63 publications have been published within this topic receiving 2097 citations. The topic is also known as: Rabbitpox virus.
Papers published on a yearly basis
Papers
TL;DR: In rabbits infected with a mutant rabbitpox virus, there was an increased number of extravasating leukocytes in the deep dermis during the early phases of infection, suggesting that members of the T1/35kDa class of secreted viral proteins bind multiple members ofThe chemokine superfamily in vitro and modulate the influx of inflammatory cells into virus-infected tissues in vivo.
249 citations
TL;DR: Several biological characters of twenty-four different strains of vaccinia, cowpox, and rabbitpox viruses have been compared to provide a basis for genetic studies of the mammalian poxviruses as discussed by the authors.
152 citations
TL;DR: Developing countermeasures to Orthopoxvirus infection is a crucial focus in biodefense research, and these efforts rely on the use of various animal models, which have its advantages and disadvantages.
Abstract: Smallpox was one of the most devastating diseases known to humanity. Although smallpox was eradicated through a historically successful vaccination campaign, there is concern in the global community that either Variola virus (VARV), the causative agent of smallpox, or another species of Orthopoxvirus could be used as agents of bioterrorism. Therefore, development of countermeasures to Orthopoxvirus infection is a crucial focus in biodefense research, and these efforts rely on the use of various animal models. Smallpox typically presented as a generalized pustular rash with 30 to 40% mortality, and although smallpox-like syndromes can be induced in cynomolgus macaques with VARV, research with this virus is highly restricted; therefore, animal models with other orthopoxviruses have been investigated. Monkeypox virus causes a generalized vesiculopustular rash in rhesus and cynomolgus macaques and induces fatal systemic disease in several rodent species. Ectromelia virus has been extensively studied in mice as a model of orthopoxviral infection in its natural host. Intranasal inoculation of mice with some strains of vaccinia virus produces fatal bronchopneumonia, as does aerosol or intranasal inoculation of mice with cowpox virus. Rabbitpox virus causes pneumonia and fatal systemic infections in rabbits and can be naturally transmitted between rabbits by an aerosol route similar to that of VARV in humans. No single animal model recapitulates all known aspects of human Orthopoxvirus infections, and each model has its advantages and disadvantages. This article provides a brief review of the Orthopoxvirus diseases of humans and the key pathologic features of animal models of Orthopoxvirus infections.
136 citations
TL;DR: A review of the literature over the past 50 years has identified a number of compounds effective in treating one or more of these infections, which include thiosemicarbazones, nucleoside and nucleotide analogs, interferon, interFERon inducers, and other unrelated compounds as discussed by the authors.
117 citations
TL;DR: It was concluded that vaccinia and rabbitpox virus are genetically the most closely related viruses investigated, although their DNA cleavage patterns are clearly distinguishable.
Abstract: Summary
The DNAs of rabbitpox, vaccinia, cowpox, ectromelia and fowl pox virus, all grown in the same host system, were cleaved with restriction endonucleases HindIII, BamI and EcoRI. The resulting digestion products were separated by electrophoresis on agarose slab gels. From the similarities and dissimilarities of the migration profiles obtained, it was concluded that vaccinia and rabbitpox virus are genetically the most closely related viruses investigated, although their DNA cleavage patterns are clearly distinguishable. Cowpox and ectromelia virus both show about the same degree of relatedness to each other as to rabbitpox and vaccinia virus. Fowl pox virus, which belongs to the genus Avipoxvirus, contains the largest genome examined (approx. 160 × 106 daltons) and the cleavage patterns of its DNA show no similarities with those of orthopoxvirus DNAs, thus indicating a very low degree of genetic relatedness. We believe that restriction analysis is a useful method for the identification and classification of poxvirus isolates.
70 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 1 |
| 2019 | 1 |
| 2018 | 1 |
| 2017 | 1 |
| 2016 | 3 |
| 2015 | 1 |