Pyrazolones

TL;DR: Progress is made in the catalytic asymmetric synthesis of pyrazoles and pyrazolones using pyrazolin-5-one derivatives using organo- and metal-catalysts.

TL;DR: Two series of novel rigid pyrazolone derivatives were synthesized and evaluated as inhibitors of Mycobacterium tuberculosis and confirm the fundamental role of the p-chlorophenyl moiety at C4 in the antimycobacterial activity.

TL;DR: This feature article summarizes these excellent research studies since 2015, including some efforts by the group of researchers studying the catalytic asymmetric synthesis of 4-monosubstituted, 4-disubst ituted, fused and spiro pyrazoles/pyrazolones.

TL;DR: Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl-2,5-diaryl-p Pyrroles as potent, orally bioavailable inhibitors of p38 kinase.