Topic
Pulpectomy
About: Pulpectomy is a research topic. Over the lifetime, 386 publications have been published within this topic receiving 5394 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: This novel stem cell therapy is the first demonstration of complete pulp regeneration, implying novel treatment to preserve and save teeth.
Abstract: Loss of pulp due to caries and pulpitis leads to loss of teeth and reduced quality of life. Thus, there is an unmet need for regeneration of pulp. A promising approach is stem cell therapy. Autologous pulp stem/progenitor (CD105(+)) cells were transplanted into a root canal with stromal cell-derived factor-1 (SDF-1) after pulpectomy in mature teeth with complete apical closure in dogs. The root canal was successfully filled with regenerated pulp including nerves and vasculature by day 14, followed by new dentin formation along the dentinal wall. The newly regenerated tissue was significantly larger in the transplantation of pulp CD105(+) cells with SDF-1 compared with those of adipose CD105(+) cells with SDF-1 or unfractionated total pulp cells with SDF-1. The pulp CD105(+) cells highly expressed angiogenic/neurotrophic factors compared with other cells and localized in the vicinity of newly formed capillaries after transplantation, demonstrating its potent trophic effects on neovascularization. Two-dimensional electrophoretic analyses and real-time reverse transcription-polymerase chain reaction analyses demonstrated that the qualitative and quantitative protein and mRNA expression patterns of the regenerated pulp were similar to those of normal pulp. Thus, this novel stem cell therapy is the first demonstration of complete pulp regeneration, implying novel treatment to preserve and save teeth.
323 citations
Journal Article•
TL;DR: Pulpectomies correctly done do not appear to contribute to adverse effects on succedaneous tooth formation but have a 20% chance of altering the path of permanent tooth eruption.
Abstract: This study evaluated factors that affected pulpectomy (PE) success and its effect on the succedaneous tooth's eruption and enamel formation. Sixty-five of 250 patients with PEs met the selection criteria and yielded 81 zinc oxide-eugenol PEs (30 incisors, 51 molars) followed a mean time of 90.8 months. Overall PE success was 77.7% with no difference between molars and incisors (P = 0.53). Enamel defects were observed in 18.7% of succedaneous teeth and were related (P = 0.005) to the pre-existing infection causing excess root resorption (>1 mm preoperative root resorption = 44.4% defects) but were not related to overretention of ZOE filler (P = 1) or length of fill (P = 0.36). The PE procedure was not related to causing succedaneous tooth defects since teeth replacing PEs showed no significant increase in the incidence of defects compared with untreated contralateral controls (P = 0.99). There was a 20% incidence of succedaneous tooth anterior cross-bite or palatal eruption following incisor PEs and 21.6% ectopic eruption of premolars following primary molar PEs. Most PEs (95.9%) were lost at their normal exfoliation time or earlier, but 35.8% needed extraction due to overretention by soft tissue at the time of shedding. Pulpectomy success rates showed that the most important preoperative predictor was the amount of primary tooth root resorption. Greater than 1 mm of root resorption resulted in only a 23.1% success rate, which was significant (P = 0.001). Pulpectomies filled short or to the apex had a significantly greater success (P = 0.011) than long fills. Pulpectomies correctly done do not appear to contribute to adverse effects on succedaneous tooth formation but have a 20% chance of altering the path of permanent tooth eruption.
217 citations
Journal Article•
TL;DR: The pulpectomy technique is described and the advantages and disadvantages of using rotary files are discussed and specific recommendations for the selection of materials and devices are made.
Abstract: This article reviews the use of nickel-titanium rotary files for root canal instrumentation in primary teeth The pulpectomy technique is described and the advantages and disadvantages of using rotary files are discussed Specific recommendations for the selection of materials and devices are made
210 citations
TL;DR: There has been a movement in pediatric dentistry to find alternatives to formocresol and calcium hydroxide for pulpotomy therapy, and Iodoform pastes are promising easier and more successful pulpectomy therapy.
206 citations
TL;DR: Root canals of dog and monkey teeth were filled with Sealapex, calcium hydroxide, or kerr Root Canal Sealer to encourage apical closure by cementum deposition and showed that SealapeX and calcium Hydroxide encourage apicals closure byementum deposition.
182 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 20 |
| 2024 | 32 |
| 2023 | 43 |
| 2022 | 71 |
| 2021 | 24 |
| 2020 | 40 |