Plithotaxis

TL;DR: This analysis provides a model of long-range mechanical communication between cells, in which plithotaxis translates local mechanical fluctuations into globally collective migration of entire tissues.

TL;DR: Results suggest that after pulp exposure, PCNA-positive cells may migrate from the central part of the radicular pulp to the sub-odontoblast cell layer and then from the apical root to the crown, which may govern pulp healing and regeneration after dental lesion.

TL;DR: This work presents an approach that enables quantitative assessment of mechanical signaling in cellular monolayers and shows that individual cells had an innately collective tendency to migrate along the axis of maximum contractile moment, and cellular plithotaxis was more strongly associated with the shear forces than with the “normal forces”.

TL;DR: Although the deformation of a stiffer cell or matrix causes larger movement-resisting forces, at the same time a larger stiffness can also promote cell migration due to a feedback between forces, deformations, and deformation speed that is mediated by the acto-myosin contractile machinery of cells.