PKCS

Abstract: The protein kinase C (PKC) family consists of 11 isoenzymes that, due to structural and enzymatic differences, can be subdivided into three groups: The Ca2+-dependent, diacylglycerol (DAG)-activated cPKCs (conventional PKCs: α, β1, β2, γ); the Ca2+-independent, DAG-activated nPKCs (novel PKCs: δ, e, η, θ, μ), and the Ca2+-dependent, DAG non-responsive aPKCs (atypical PKCs: ζ, λ/ι). PKCμ is a novel PKC, but with some special structural and enzymatic properties.

Abstract: Various membrane lipid metabolites, generated by phospholipases C and D (PLCs, PLDs), are known to regulate the activities of protein kinases C (PKCs) and GTP-ase activating proteins (GAPs) in a range of cellular processes. Conventional Ca(2+)-dependent PKCs (alpha, beta I, beta II, and gamma), PLCs and various GAPs are all known to contain copies of a phospholipid-binding domain, termed C2 or CalB. Here we recognize that C2 domains are also present in "new" Ca(2+)-independent PKCs (delta, epsilon, eta, and theta), other kinases, a eukaryotic PLD, the breakpoint cluster region (BCR) gene product, and two further GAPS. Twenty-two previously unrecognized C2 domain sequences are presented, which include a single copy in the mammalian poreforming proteins, perforin.

Abstract: PKCS #12 v1.1 describes a transfer syntax for personal identity information, including private keys, certificates, miscellaneous secrets, and extensions. Machines, applications, browsers, Internet kiosks, and so on, that support this standard will allow a user to import, export, and exercise a single set of personal identity information. This standard supports direct transfer of personal information under several privacy and integrity modes. This document represents a republication of PKCS #12 v1.1 from RSA Laboratories' Public Key Cryptography Standard (PKCS) series. By publishing this RFC, change control is transferred to the IETF.

Abstract: Hormones, growth factors, electrical stimulation, and cell–cell interactions regulate numerous cellular processes by altering the levels of second messengers, thus influencing biochemical reactions inside the cells. The Protein Kinase C family (PKCs) is a group of serine/threonine kinases that are dependent on calcium (Ca2+), diacylglycerol, and phospholipids. Signaling pathways that induce variations on the levels of PKC activators have been implicated in the regulation of diverse cellular functions and, in turn, PKCs are key regulators of a plethora of cellular processes, including proliferation, differentiation, and tumorigenesis. Importantly, PKCs contain regions, both in the N-terminal regulatory domain and in the C-terminal catalytic domain, that are susceptible to redox modifications. In several pathophysiological conditions when the balance between oxidants, antioxidants, and alkylants is compromised, cells undergo redox stress. PKCs are cell-signaling proteins that are particularly sensi...