Topic
PIGF
About: PIGF is a research topic. Over the lifetime, 238 publications have been published within this topic receiving 8370 citations. The topic is also known as: phosphatidylinositol glycan anchor biosynthesis class F & OORS.
Papers published on a yearly basis
Papers
TL;DR: Purified PIGF isoforms had little or no direct mitogenic or permeability-enhancing activity, but were able to significantly potentiate the action of low concentrations of VEGF in vitro and, more strikingly, in vivo.
1,208 citations
TL;DR: It is proposed that sFlt-1, PIGF, and sFelt-1/PIGF ratio may be of value in the prediction of PE and in the differential diagnosis of patients with atypical presentations of PE, and perhaps in the differentiation diagnosis of women with chronic hypertension suspected to develop superimposed PE.
465 citations
Journal Article•
TL;DR: Results suggest that VEGF, PIGF, and basic fibroblast growth factor are cooperatively working to increase the angiogenesis in renal cell carcinoma in vivo.
Abstract: The presence of mRNAs for vascular endothelial growth factor (VEGF) and a VEGF-related protein, placenta growth factor (PIGF) was examined in 29 cases of renal cell carcinoma tissues and adjacent normal kidney tissues and in 4 human renal cell carcinoma cell lines. Northern blot analysis showed that 26 of 27 hypervascular renal cell carcinoma tissues (96%) exhibited a markedly elevated level (3-13 fold) of VEGF mRNA compared to the adjacent normal kidney tissues. Even tumors of small size, whenever they were hypervascular, overexpressed VEGF mRNA. We also demonstrated that mRNA for PIGF was expressed in 21 of 23 hypervascular renal cell carcinoma tissues (91%) but was not detected in the adjacent normal kidney tissues. Two hypovascular carcinoma tissues neither overexpressed VEGF mRNA nor had PIGF mRNA. VEGF mRNA was detected in four human renal cell carcinoma cell lines, while PIGF mRNA was not. There was no difference in the level of basic fibroblast growth factor mRNA between tumor tissues and normal kidney tissue, although our previous study demonstrated elevated basic fibroblast growth factor protein in the serum of renal cell carcinoma patients (K. Fujimoto et al., Biochem. Biophys. Res. Commun., 180: 386-392, 1991). Taken together, these results suggest that VEGF, PIGF, and basic fibroblast growth factor are cooperatively working to increase the angiogenesis in renal cell carcinoma in vivo.
434 citations
TL;DR: Changes in vascular endothelial growth factor and placenta growth factor expression and function provide a molecular explanation for the observed poor angiogenesis in the pathogenesis of IUGR.
391 citations
Journal Article•
TL;DR: This is the first study to demonstrate that PIGF-1 can induce angiogenesis in vivo and stimulate the migration and proliferation of endothelial cells in vitro.
319 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 22 |
| 2020 | 12 |
| 2019 | 11 |
| 2018 | 18 |
| 2017 | 16 |
| 2016 | 9 |