Topic
Phosphorane
About: Phosphorane is a research topic. Over the lifetime, 1146 publications have been published within this topic receiving 14498 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: In this article, a review of the processes occurring on the treatment of triphenylphosphane with tetrachloromethane are first reported; a key role is played here by (trichlormethyl)phosphonium chloride which reacts with a further amount of the phosphane to give the stable salt [chloro(triphenyl phos-phoranediyl)methyl]triphenynphosphoni chloride by way of dichlorophosphorane and (dichloromethemylene)ph phosphorane that is detectable only
Abstract: In this review the processes occurring on the treatment of triphenylphosphane with tetrachloromethane are first reported; a key role is played here by (trichloromethyl)phosphonium chloride which reacts with a further amount of the phosphane to give the stable salt [chloro(triphenylphos-phoranediyl)methyl]triphenylphosphonium chloride by way of dichlorophosphorane and (dichloromethylene)phosphorane that is detectable only as an intermediate. The preparative application of the two-component system as a chlorinating, dehydrating, and P—N-linking reagent is ascribable to “phosphorylation” of the substrate in question through several reactive species. In these applications the reactions with the substrate compete with reactions of the two-component system with itself, so that the overall course of the reaction is in nearly all cases much more complex than was previously assumed. Nevertheless. very good results can be achieved by the use of this reagent, high yields and mild reaction conditions being characteristic.
896 citations
TL;DR: The atomic-resolution structure of a high-energy reaction intermediate stabilized in the active site of an enzyme is reported, revealing a stabilized pentacovalent phosphorane formed in the phosphoryl transfer from the C(1)O of glucose 1,6-(bis)phosphate to the nucleophilic Asp8 carboxylate.
Abstract: Enzymes provide enormous rate enhancements, unmatched by any other type of catalyst. The stabilization of high-energy states along the reaction coordinate is the crux of the catalytic power of enzymes. We report the atomic-resolution structure of a high-energy reaction intermediate stabilized in the active site of an enzyme. Crystallization of phosphorylated beta-phosphoglucomutase in the presence of the Mg(II) cofactor and either of the substrates glucose 1-phosphate or glucose 6-phosphate produced crystals of the enzyme-Mg(II)-glucose 1,6-(bis)phosphate complex, which diffracted x-rays to 1.2 and 1.4 angstroms, respectively. The structure reveals a stabilized pentacovalent phosphorane formed in the phosphoryl transfer from the C(1)O of glucose 1,6-(bis)phosphate to the nucleophilic Asp8 carboxylate.
332 citations
185 citations
TL;DR: A review on syntheses, chemical reactions, structures and bonding of phosphorane iminato complexes of main group elements is given in this paper, where the ligand group is not known in the ionic state.
158 citations
152 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2024 | 3 |
| 2023 | 2 |
| 2022 | 8 |
| 2021 | 4 |
| 2020 | 9 |
| 2019 | 8 |