Showing papers on "Phenotypic screening published in 2001"
TL;DR: A high throughput, phenotypic screen in cells that led to the discovery of a class of sirtuin inhibitors, and structure-activity relationship analysis of the compounds identified a key hydroxy-napthaldehyde moiety that is necessary and sufficient for inhibitory activity.
587 citations
TL;DR: A phenotypic screen resulting in the discovery of novel localization peptides that were not cell type-specific suggests that this methodology may be applied to other screens in cells derived from diseased organisms, and illustrates the use of intracellular combinatorial peptide chemistry in mammalian cells.
55 citations
6 citations
TL;DR: Industrialized mouse reverse genetics is being used to determine gene function in the context of mammalian physiology and to identify the best targets for drug development.