Topic
Phaedranassa
About: Phaedranassa is a research topic. Over the lifetime, 10 publications have been published within this topic receiving 38 citations.
Papers
TL;DR: The results show that Amaryllidaceae species from Ecuador are a potential source of new drugs for the palliative treatment of AD.
Abstract: It is estimated that 50 million people in the world live with dementia, 60–70% of whom suffer from Alzheimer’s disease (AD). Different factors are involved in the development of AD, including a reduction in the cholinergic neurotransmission level. The Amaryllidaceae plant family contains an exclusive, large, and still understudied alkaloid group characterized by a singular skeleton arrangement and a broad spectrum of biological activities. The chemistry and biodiversity of Ecuadorian representatives of the Phaedranassa genus (Amaryllidaceae) have not been widely studied. In this work, five Ecuadorian Phaedranassa species were examined in vitro for their activity towards the enzymes acetyl- (AChE) and butyrylcholinesterase (BuChE), and the alkaloid profile of bulb extracts was analyzed by GC-MS. The species Phaedranassa cuencana and Phaedranassa dubia showed the most AChE and BuChE inhibitory activity, respectively. To obtain insight into the potential role of the identified alkaloids in these inhibitory effects, docking experiments were carried out, and cantabricine showed in silico inhibitory activity against both cholinesterase structures. Our results show that Amaryllidaceae species from Ecuador are a potential source of new drugs for the palliative treatment of AD.
16 citations
TL;DR: This is the first study about the alkaloid profile and biological potential of P. dubia and P. brevifolia species and some alkaloids detected in these Amaryllidaceae species presented higher estimated binding free energy toward BuChE than galanthamine.
9 citations
TL;DR: These loci are the first microsatellite primers isolated for Amaryllidaceae and will be utilized to investigate patterns of genetic variation of P. tunguraguae, which will contribute data relevant to the conservation of the species.
Abstract: Phaedranassa tunguraguae is an endangered species endemic to Ecuador. Eight highly polymorphic microsatellite loci were isolated from an enriched genomic library for this species. Levels of polymorphism were evaluated using a total of 31 individuals from a single natural population. An average of 14.1 alleles per locus was detected, and observed heterozygosity ranged from 0.387 to 0.903. All but one locus depart significantly from Hardy– Weinberg equilibrium. These loci are the first microsatellite primers isolated for Amaryllidaceae and will be utilized to investigate patterns of genetic variation of P. tunguraguae , which will contribute data relevant to the conservation of the species.
7 citations
TL;DR: Despite its occurrence on cliffs along roads, the species has remained unnoticed by previous floristic explorers and is described as a distinctive new species in this genus.
Abstract: Phaedranassa Herbert (1845: misc. 16) is a small genus of bulbous, terrestrial geophytes comprising some eleven species, eight endemic to Ecuador, three known from Colombia, and one from Costa Rica (Meerow 1990). Most of the species are narrow endemics known from few collections. All but one of the species known from Ecuador are considered to be under some threat (IUCN, 2014) because of their restricted distribution and threatened habitat where they occur. Five of them are regarded as Endangered and one as Vulnerable (Oleas 2011). Here we describe a distinctive new species in this genus. Despite its occurrence on cliffs along roads, the species has remained unnoticed by previous floristic explorers.
5 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 1 |
| 2020 | 1 |
| 2018 | 1 |
| 2015 | 1 |
| 2013 | 1 |
| 2011 | 1 |