Pergularia

Abstract: Pergularia daemia (Forsk.) Chiov. (Asclepiadaceae), a wild plant of the arid zone of Rajasthan, hasdemonstrated significant antiinflammatory, antipyretic and analgesic activities including the release of prostaglandin. © 1998 John Wiley & Sons, Ltd.

Abstract: Objective: Management of cancer without any side effects is still a challenge for the medicinal system. This leads to an increasing search for improved anticancer drugs. Few of plant products have been used in traditional medicine for thousands of years and have been drawing of great deal of attention to suppress cancer. The main objective of this study is to evaluate the antiproliferative effect of Pergularia daemia (Forsk) against KB cells. Methods: Different concentrations of areal part of Pergularia daemia methanolic extract (10,20,40,80,160,320 µg/ml) were subjected to cytotoxic study. The antiproliferative effect of PDME was determined by MTT assay, analysis of ROS generation, mitochondrial membrane potential, cell cycle arrest and antioxidant status. Result: Increased level of intracellular ROS, lipid peroxidation marker (TBARS), DNA damage (comet assay), apoptotic death and cell cycle arrest in PDME treated cells. Whereas decreased activity of antioxidants and altered mitochondrial membrane potential were observed in PDME treated cells. Conclusion: The current investigation suggested that the phyto constituents of Pergularia daemia responsible for anticancer activity. Thus the long term consumption of Pergularia daemia could be considered and promoted as a adjuvant therapy for various malignancy.