Topic
PEG 400
About: PEG 400 is a research topic. Over the lifetime, 1107 publications have been published within this topic receiving 21590 citations. The topic is also known as: polyethylene glycol 400.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: In this article, polyethylene glycol (PEG) of three different molecular weights were used as the polymeric additives in the casting solution of polysulfone (PSf) by phase inversion method.
466 citations
TL;DR: The mechanical properties of β-lactoglobulin (β-Lg) films plasticized with different plasticizers were determined in this article, where six plasticizer types were studied over a range of concentrations.
444 citations
TL;DR: In this article, the performance of asymmetric polyethersulfone ultrafiltration flat sheet membranes with polyethylene glycol (PEG) of different molecular weight as additives was reported.
368 citations
TL;DR: In this article, the performance of asymmetric polysulfone membranes was evaluated in terms of pure water flux (PWF), protein rejection, porosity, contact angle, tensile strength, and elongation at break.
348 citations
TL;DR: Physico-chemical properties of the solvent such as polarity, intermolecular interactions, and the ability of the liquid to form a hydrogen bond with the drug molecules were found to be the major factors involved in the dissolution of drugs by pure solvents.
Abstract: This study examined the solubility enhancement of 4 cox-2 inhibitors, celecoxib, rofecoxib, meloxicam, and nimesulide, using a series of pure solvents and solvent mixtures Water, alcohols, glycols, glycerol, and polyethylene glycol 400 (PEG 400) were used as solvents and water-ethanol, glycerol-ethanol, and polyethylene glycol-ethanol were used as mixed-solvent systems A pH-solubility profile of drugs was obtained in the pH range 70 to 109 using 005M glycine-sodium hydroxide buffer solutions Lower alcohols, higher glycols, and PEG 400 were found to be good solvents for these drugs The aqueous solubility of celecoxib, rofecoxib, and nimesulide could be enhanced significantly by using ethanol as the second solvent Among the mixed-solvent systems, PEG 400-ethanol system had highest solubilization potential In the case of meloxicam and nimesulide, solubility increased significantly with increase in pH value Physico-chemical properties of the solvent such as polarity, intermolecular interactions, and the ability of the solvent to form a hydrogen bond with the drug molecules were found to be the major factors involved in the dissolution of drugs by pure solvents The greater the difference in the polarity of the 2 solvents in a given mixed solvent, the greater was the solubilization power However, in a given mixed-solvent system, the solubilization power could not be related to the polarity of the drugs Significance of the solubility data in relation to the development of formulations has also been discussed in this study
302 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 1 |
| 2024 | 5 |
| 2023 | 10 |
| 2022 | 13 |
| 2021 | 45 |
| 2020 | 42 |