Topic
Patchoulol
About: Patchoulol is a research topic. Over the lifetime, 99 publications have been published within this topic receiving 2342 citations. The topic is also known as: patchouli camphor & patchoulic alcohol.
Papers published on a yearly basis
Papers
TL;DR: The aim of the present review is to provide comprehensive knowledge on the phytochemistry and pharmacological activities of essential oil and different plant extracts of patchouli based on the available scientific literature to provide a potential guide in exploring the use of main active compounds ofpatchouli in various medical fields.
Abstract: Pogostemon cablin Benth. (patchouli) is an important herb which possesses many therapeutic properties and is widely used in the fragrance industries. In traditional medicinal practices, it is used to treat colds, headaches, fever, nausea, vomiting, diarrhea, abdominal pain, insect and snake bites. In aromatherapy, patchouli oil is used to relieve depression, stress, calm nerves, control appetite and to improve sexual interest. Till now more than 140 compounds, including terpenoids, phytosterols, flavonoids, organic acids, lignins, alkaloids, glycosides, alcohols, aldehydes have been isolated and identified from patchouli. The main phytochemical compounds are patchouli alcohol, α-patchoulene, β-patchoulene, α-bulnesene, seychellene, norpatchoulenol, pogostone, eugenol and pogostol. Modern studies have revealed several biological activities such as antioxidant, analgesic, anti-inflammatory, antiplatelet, antithrombotic, aphrodisiac, antidepressant, antimutagenic, antiemetic, fibrinolytic and cytotoxic activities. However, some of the traditional uses need to be verified and may require standardizing and authenticating the bioactivity of purified compounds through scientific methods. The aim of the present review is to provide comprehensive knowledge on the phytochemistry and pharmacological activities of essential oil and different plant extracts of patchouli based on the available scientific literature. This information will provide a potential guide in exploring the use of main active compounds of patchouli in various medical fields.
355 citations
TL;DR: This simple test case of synthetic biology demonstrates that engineering the spatial organization of metabolic enzymes around a branch point has great potential for diverting flux toward a desired product.
Abstract: The ability to transfer metabolic pathways from the natural producer organisms to the well-characterized cell factory Saccharomyces cerevisiae is well documented. However, as many secondary metabolites are produced by collaborating enzymes assembled in complexes, metabolite production in yeast may be limited by the inability of the heterologous enzymes to collaborate with the native yeast enzymes. This may cause loss of intermediates by diffusion or degradation or due to conversion of the intermediate through competitive pathways. To bypass this problem, we have pursued a strategy in which key enzymes in the pathway are expressed as a physical fusion. As a model system, we have constructed several fusion protein variants in which farnesyl diphosphate synthase (FPPS) of yeast has been coupled to patchoulol synthase (PTS) of plant origin (Pogostemon cablin). Expression of the fusion proteins in S. cerevisiae increased the production of patchoulol, the main sesquiterpene produced by PTS, up to 2-fold. Moreover, we have demonstrated that the fusion strategy can be used in combination with traditional metabolic engineering to further increase the production of patchoulol. This simple test case of synthetic biology demonstrates that engineering the spatial organization of metabolic enzymes around a branch point has great potential for diverting flux toward a desired product.
216 citations
TL;DR: Interestingly, the yield of the different in vitro reaction products resembles quantitatively and qualitatively the profile of sesquiterpenes found in patchouli oil extracted from plants, suggesting that a single terpene synthase is responsible for the bulk and diversity of terPene products produced in planta.
194 citations
TL;DR: In this paper, patchouli essential oil was extracted with supercritical carbon dioxide (scCO 2 ) under different conditions of pressure (8.5 and 14 MPa) and temperature (40 and 50 °C).
Abstract: Patchouli essential oil is an important raw material for the perfume and cosmetics industries, besides being used as a natural additive for food flavoring. Patchoulol and α-patchoulene are important compounds of patchouli essential oil, and their concentrations are directly proportional to the quality of the oil. Nowadays, the usual method employed to obtain patchouli essential oil is steam distillation; however, this causes thermal degradation of some oil compounds. In this study patchouli essential oil was extracted with supercritical carbon dioxide (scCO 2 ) under different conditions of pressure (8.5 and 14 MPa) and temperature (40 and 50 °C) and also by steam distillation to compare the extraction methods. It was demonstrated that the extraction with supercritical carbon dioxide provided a higher yield and a better quality of patchouli essential oil.
192 citations
TL;DR: It is shown here that the miR156-targeted SPL transcription factor plays an important role in the spatiotemporal regulation of sesquiterpene biosynthesis, and this finding suggests a new strategy to engineer plants for accelerated growth with enhanced production of terpenoids.
168 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2022 | 1 |
| 2021 | 8 |
| 2020 | 8 |
| 2019 | 5 |
| 2018 | 5 |
| 2017 | 3 |