Topic
Passive immunity
About: Passive immunity is a research topic. Over the lifetime, 1033 publications have been published within this topic receiving 27405 citations.
Papers published on a yearly basis
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Papers
TL;DR: A comprehensive review of the literature of passive transfer in calves including factors that affect passive transfer status, testing modalities, effects of failure of Passive transfer on baseline mortality, consequences of failure, and some treatment options is presented.
Abstract: Passive transfer of colostral immunoglobulins has long been accepted as imperative to optimal calf health Many factors, including timing of colostrum ingestion, the method and volume of colostrum administration, the immunoglobulin concentration of the colostrum ingested, and the age of the dam have been implicated in affecting the optimization of absorption The practice of colostrum pooling, the breed and presence of the dam, and the presence of respiratory acidosis in the calf also may affect passive transfer Various tests have been reported to accurately measure passive transfer status in neonatal calves The radial immunodiffusion and the enzyme-linked immunosorbent assay (ELISA) are the only tests that directly measure serum IgG concentration All other available tests including serum total solids by refractometry, sodium sulfite turbidity test, zinc sulfate turbidity test, serum gamma-glutamyl transferase activity, and whole blood glutaraldehyde gelation estimate serum IgG concentration based on concentration of total globulins or other proteins whose passive transfer is statistically associated with that of IgG This paper presents a comprehensive review of the literature of passive transfer in calves including factors that affect passive transfer status, testing modalities, effects of failure of passive transfer on baseline mortality, consequences of failure of passive transfer, and some treatment options Many previously accepted truisms regarding passive transfer in calves should be rejected based on the results of recent research
752 citations
TL;DR: The immunologic response as it develops, the components of passive immunity, and the immune response of young calves are covered, and interference from maternal immunity in the development of specific immunity and vaccine strategies for developing protection against pathogens in calves are discussed.
Abstract: In this article we cover the immunologic response as it develops, the components of passive immunity, and the immune response of young calves. We discuss interference from maternal immunity in the development of specific immunity and vaccine strategies for developing protection against pathogens in calves.
413 citations
TL;DR: The maternal supply of IgG and piglet absorption of IgGs in naturally suckling piglets of modern genotype are assessed and relationships between acquisition of passive immunity and development of active immunity addressed.
353 citations
TL;DR: The characteristics of bovine Igs and the complement system to be exploited as potential ingredients for health-promoting functional foods are dealt with.
Abstract: The importance of colostrum for the growth and health of newborn offspring is well known. In bovine colostrum, the antibody (immunoglobulin) complement system provides a major antimicrobial effect against a wide range of microbes and confers passive immunity until the calf's own immune system has matured. Bovine serum and lacteal secretions contain three major classes of immunoglobulins: IgG, IgM and IgA. The immunoglobulins are selectively transported from the serum into the mammary gland, as a result of which the first colostrum contains very high concentrations of immunoglobulins (40-200 mg/ml). IgG1 accounts for over 75 % of the immunoglobulins in colostral whey, followed by IgM, IgA and IgG2. All these immunoglobulins decrease within a few days to a total immunoglobulin concentration of 0.7-1.0 mg/ml, with IgG1 representing the major Ig class in milk throughout the lactation period. Together with the antibodies absorbed from colostrum after birth, the complement system plays a crucial role in the passive immunisation of the newborn calf. The occurrence of haemolytic or bactericidal complement activity in bovine colostrum and milk has been demonstrated in several studies. This review deals with the characteristics of bovine Igs and the complement system to be exploited as potential ingredients for health-promoting functional foods.
346 citations
TL;DR: An important part of the resistance to disease with which an adult mammal is equipped is due to the production of circulating antibodies, molecules of soluble protein adapted to react specifically with foreign substances that have got into the system and induced their formation.
Abstract: I . INTRODUCTION (I) Nature and production of antibodies An important part of the resistance to disease with which an adult mammal is equipped is due to the production of circulating antibodies. These are molecules of soluble protein adapted to react specifically with foreign substances, known as antigens, that have got into the system and induced their formation. Invasive organisms, or organic materials, such as red blood corpuscles from another animal, gaining access to the system by injection or other means, may act as antigens. Antibodies are in the globulin fraction of the serum proteins of the blood, as a rule mainly in the y-globulins, though sometimes also in the other fractions of the globulins. These fractions of the serum proteins can be separated and characterized by physical and chemical means; notably by electrophoresis, depending on the characteristic speed with which they migrate in an electrical field, by ultracentrifugation, by fractional precipitation, or by chromatographic separation. Even in the purest preparations so obtained from highly immune sera, a given antibody usually constitutes only a part, sometimes a small part, of the globulin. The globulins are large protein molecules and those in the ultracentrifugal fractions containing antibodies have molecular weights either around I 60,000 or near
341 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 17 |
| 2024 | 26 |
| 2023 | 36 |
| 2022 | 62 |
| 2021 | 43 |
| 2020 | 43 |