Topic
para-Methoxyamphetamine
About: para-Methoxyamphetamine is a research topic. Over the lifetime, 15 publications have been published within this topic receiving 292 citations. The topic is also known as: benzeneethanamine, 4-methoxy-α-methyl- & 4-methoxy-α-methyl-benzeneethanamine.
Papers
TL;DR: Data suggest that the acute adverse effects of PMA are more likely to be associated with alterations in serotonergic rather than dopaminergic neurotransmission.
Abstract: 1.
1. This study was prompted by recent deaths that have occurred after recreational administration of the substituted amphetamine para-methoxyamphetamine (PMA). Because relatively little is known regarding its mechanism(s) of action, its effects on physiological, behavioural and neurochemical parameters were compared with the well known effects of 3,4-methylenedioxymethamphetamine (MDMA).
2.
2. Equivalent doses of PMA (5-20 mg/kg) produced greater hypothermia than MDMA at an ambient temperature of 20 °C. At 30 °C, PMA continued to evoke hypothermia except the highest dose where hyperthermia ensued. MDMA altered body temperature only at the highest dose where hyperthermia also resulted.
3.
3. At both 20 and 30 °C, MDMA stimulated locomotor activity whereas PMA had modest effects and then, only at high doses.
4.
4. In vivo chronoamperometry was used to measure the effect of MDMA and PMA on release, and inhibition of uptake, of serotonin (5-HT) and dopamine (DA) in the dorsal striatum of anaesthetised rats. As expected, MDMA evoked release of DA and inhibited uptake of both DA and 5-HT. By contrast, PMA was a relatively weak releasing agent and did not inhibit DA uptake. However, PMA potently inhibited uptake of 5-HT.
5.
5. Taken together these data suggest that the acute adverse effects of PMA are more likely to be associated with alterations in serotonergic rather than dopaminergic neurotransmission.
51 citations
TL;DR: In vivo data demonstrate in vivo brain region variability in the ability of PMA and MDMA to evoke release of neurotransmitter, that clearance of 5-HT in the striatum is mediated by both the SERT and the DAT, and that PMA is a more efficacious inhibitor of5-HT clearance in the hippocampus than MDMA.
37 citations
TL;DR: Examination of the effects of co-administration of MDMA and PMA with moclobemide on extracellular concentrations of 5-HT and 5-hydroxy indol acetic acid in the striatum of the rat suggests this drug may cause increased 5- HT related toxicity similar to that reported with PMA.
32 citations
TL;DR: Results are consistent with previous findings that the DA-depleting psychostimulants AMPH and METH produce reactive gliosis whereas the 5-HT- Depleting drugs MDMA and PMA, as well as the known 5- HT selective neurotoxin 5,7-DHT, do not produce an appreciable glial response.
31 citations
TL;DR: These results suggest that behavioral aspects of thermoregulation are important in assessing the potential of individual drugs to cause harmful increases in core temperature.
Abstract: Rationale
Cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), and para-methoxyamphetamine (PMA) disrupt normal thermoregulation in humans, with PMA being associated with more severe cases of hyperthermia. Harm minimization advice on how to prevent overheating depends on appropriate thermoregulatory behavior by drug users.
28 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2018 | 1 |
| 2007 | 5 |
| 2006 | 1 |
| 2005 | 3 |
| 2000 | 1 |
| 1992 | 1 |