Topic
Padimate O
About: Padimate O is a research topic. Over the lifetime, 32 publications have been published within this topic receiving 980 citations. The topic is also known as: Padimate-O & Padimate O.
Papers
TL;DR: Although the sunblock based on BNPs contained less than 5 wt% of the UV-filter concentration found in commercial standards, the anti-UV effect was comparable when tested in two murine models and the BNP-based sunblock significantly reduced double-stranded DNA breaks when compared to a commercial sunscreen formulation.
Abstract: The majority of commercial sunblock preparations use organic or inorganic ultraviolet (UV) filters. Despite protecting against cutaneous phototoxicity, direct cellular exposure to UV filters has raised a variety of health concerns. Here, we show that the encapsulation of padimate O (PO)—a model UV filter—in bioadhesive nanoparticles (BNPs) prevents epidermal cellular exposure to UV filters while enhancing UV protection. BNPs are readily suspended in water, facilitate adherence to the stratum corneum without subsequent intra-epidermal or follicular penetration, and their interaction with skin is water resistant yet the particles can be removed via active towel drying. Although the sunblock based on BNPs contained less than 5 wt% of the UV-filter concentration found in commercial standards, the anti-UV effect was comparable when tested in two murine models. Moreover, the BNP-based sunblock significantly reduced double-stranded DNA breaks when compared with a commercial sunscreen formulation. A water-resistant sunblock based on bioadhesive nanoparticles encapsulating a model ultraviolet filter at low concentrations adheres to the stratum corneum without subsequent intra-epidermal or follicular penetration.
195 citations
TL;DR: In this article, the photolysis reactions of three compounds commonly used as a sunscreen agents, Parsol 1789 (1]-4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3- propanedione), Oxybenzone ((2-hydroxy-4methoenyl)-phenylmethanone) and Padimate O (2-ethylhexyl-4-(dimethylamino)benzoate), were investigated to provide a chemical background to aid in the understanding of
Abstract: The photolysis reactions of three compounds commonly used as a sunscreen agents, Parsol 1789 (1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3- propanedione), Oxybenzone ((2-hydroxy-4-methoxyphenyl)phenyl-methanone) and Padimate O (2-ethylhexyl-4-(dimethylamino)benzoate), were investigated to provide a chemical background to aid in the understanding of the photosensitization of the sunscreen agents. Photolysis was carried out in cyclohexane for 70–140 h using a mercury vapor lamp (450W) without excluding oxygen. Irradation of Parsol 1789 in cyclohexane yielded tert -butylbenzene, p - tert -butylbenzoic acid and p -methoxybenzoic acid; products obtained from the combination of the sunscreen with the solvent included the cyclohexyl esters of p -methoxybenzoic acid, p - tert -butylbenzoic acid and methanoic acid; products obtained from the solvent included cyclohexanol, cyclohexanone and dicyclohexyl ether. Irradiation of Oxybenzone in the cyclohexane for 100 h produced no detectable products by either gas or liquid chromatographic analysis. Oxybenzone was recovered unchanged and no products were observed from the photoinitiated reaction of oxygen with the solvent. Irradiation of Padimate O in cyclohexane yielded the ethylhexyl esters of p -aminobenzoic acid, p -monomethylaminobenzoic acid and p -dimethylamino ( o/m )-methylbenzoic acid, as well as products from the photoinitiated reaction of oxygen with the solvent.
105 citations
TL;DR: The mutagenicity of a UV‐B sunscreen ingredient called Padimate‐O or octyl dimethyl PABA, which is identical to an industrial chemical that generates free radicals when illuminated, suggests that some sunscreens could, while preventing sunburn, contribute to sunlight‐related cancers.
100 citations
TL;DR: Sunscreens can protect from local and systemic immunosuppression, although this protection is limited and is not related to the sun protection factor of the sunscreens or the minimal erythema dose of the mouse strain.
98 citations
TL;DR: Results indicate that application of sunscreen does not retard the development of suppression of CHS following repeated UV exposure under conditions where erythema is not clinically observed, and may not be a good end point for assessing systemic immune suppression and its consequences.
68 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2019 | 2 |
| 2017 | 1 |
| 2015 | 3 |
| 2013 | 1 |
| 2009 | 1 |
| 2008 | 2 |