Topic
PACX
About: PACX is a research topic. Over the lifetime, 2 publications have been published within this topic receiving 17 citations. The topic is also known as: Private Automatic Computer eXchange.
Papers
TL;DR: In this article, the authors investigate two levels at which the pH regulatory system is transcriptionally moderated by pH and identify and characterise a new component of pH regulatory machinery, PacX.
Abstract: The A spergillus nidulans PacC transcription factor mediates gene regulation in response to alkaline ambient pH which, signalled by the Pal pathway, results in the processing of PacC72 to PacC27 via PacC53. Here we investigate two levels at which the pH regulatory system is transcriptionally moderated by pH and identify and characterise a new component of the pH regulatory machinery, PacX. Transcript level analysis and overexpression studies demonstrate that repression of acid‐expressed pal F, specifying the Pal pathway arrestin, probably by PacC27 and/or PacC53, prevents an escalating alkaline pH response. Transcript analyses using a reporter and constitutively expressed pac C trans‐alleles show that pac C preferential alkaline‐expression results from derepression by depletion of the acid‐prevalent PacC72 form. We additionally show that pac C repression requires PacX. pac X mutations suppress PacC processing recalcitrant mutations, in part, through derepressed PacC levels resulting in traces of PacC27 formed by pH‐independent proteolysis. pac X was cloned by impala transposon mutagenesis. PacX, with homologues within the Leotiomyceta, has an unusual structure with an amino‐terminal coiled‐coil and a carboxy‐terminal zinc binuclear cluster. pacX mutations indicate the importance of these regions. One mutation, an unprecedented finding in A . nidulans genetics, resulted from an insertion of an endogenous Fot1‐like transposon.
17 citations
TL;DR: Three elevenventh-century English coin types bear legends on the reverse field which are customarily interpreted as forms of the Latin word pax, "peace" as discussed by the authors, which is difficult for a historian to understand why such a gesture should have been made on the three occasions in the eleventh century indicated by numismatic chronology.
Abstract: Three eleventh-century English coin types bear legends on the reverse field which are customarily interpreted as forms of the Latin word pax, ‘peace’. The earliest is the Pacx type of Edward the Confessor, which takes its name from the letters p-a-c-x distributed in the four angles of a cross (see fig. 2a); the second is the sole, Pax, type of Harold II, which has the legend pax disposed horizontally within an inner circle (see fig. 2b); and finally there is the Paxs type of William I, which has four annulets within the angles of a cross, each containing one letter of the legend paxs (see fig. 2c). The issue of a type conveying ‘peace’ could be, and has been, regarded as a political gesture arising from specific circumstances, but it is difficult for a historian to understand why such a gesture should have been made on the three occasions in the eleventh century indicated by numismatic chronology – at the beginning of the reigns of Edward and Harold, and again two decades after the accession of William.
3 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2015 | 1 |
| 1978 | 1 |