Topic
Pacemaker syndrome
About: Pacemaker syndrome is a research topic. Over the lifetime, 223 publications have been published within this topic receiving 6486 citations.
Papers published on a yearly basis
Papers
Duke University1, Harvard University2, Emory University3, University of Western Ontario4, University of Missouri5, National Institutes of Health6, Baptist Health7, Oregon Health & Science University8, Virginia Commonwealth University9, Mount Sinai St. Luke's and Mount Sinai Roosevelt10, Tufts University11, Thomas Jefferson University12, University of California, San Francisco13
TL;DR: Overall, dual-chamber pacing offers significant improvement as compared with ventricular pacing, and reduces the risk of atrial fibrillation, reduces signs and symptoms of heart failure, and slightly improves the quality of life.
Abstract: Background Dual-chamber (atrioventricular) and single-chamber (ventricular) pacing are alternative treatment approaches for sinus-node dysfunction that causes clinically significant bradycardia. However, it is unknown which type of pacing results in the better outcome. Methods We randomly assigned a total of 2010 patients with sinus-node dysfunction to dual-chamber pacing (1014 patients) or ventricular pacing (996 patients) and followed them for a median of 33.1 months. The primary end point was death from any cause or nonfatal stroke. Secondary end points included the composite of death, stroke, or hospitalization for heart failure; atrial fibrillation; heart-failure score; the pacemaker syndrome; and the quality of life. Results The incidence of the primary end point did not differ significantly between the dual-chamber group (21.5 percent) and the ventricular-paced group (23.0 percent, P=0.48). In patients assigned to dual-chamber pacing, the risk of atrial fibrillation was lower (hazard ratio, 0.79; 9...
1,001 citations
TL;DR: Physiologic pacing provides little benefit over ventricular pacing for the prevention of stroke or death due to cardiovascular causes and the effect on the rate of atrial fibrillation was not apparent until two years after implants.
Abstract: Background Evidence suggests that physiologic pacing (dual-chamber or atrial) may be superior to single-chamber (ventricular) pacing because it is associated with lower risks of atrial fibrillation, stroke, and death. These benefits have not been evaluated in a large, randomized, controlled trial. Methods At 32 Canadian centers, patients without chronic atrial fibrillation who were scheduled for a first implantation of a pacemaker to treat symptomatic bradycardia were eligible for enrollment. We randomly assigned patients to receive either a ventricular pacemaker or a physiologic pacemaker and followed them for an average of three years. The primary outcome was stroke or death due to cardiovascular causes. Secondary outcomes were death from any cause, atrial fibrillation, and hospitalization for heart failure. Results A total of 1474 patients were randomly assigned to receive a ventricular pacemaker and 1094 to receive a physiologic pacemaker. The annual rate of stroke or death due to cardiovascular cause...
819 citations
TL;DR: Quality of life improved significantly after pacemaker implantation, but there were no differences between the two pacing modes in either the quality of life or prespecified clinical outcomes (including cardiovascular events or death).
Abstract: Background Standard clinical practice permits the use of either single-chamber ventricular pacemakers or dual-chamber pacemakers for most patients who require cardiac pacing. Ventricular pacemakers are less expensive, but dual-chamber pacemakers are believed to be more physiologic. However, it is not known whether either type of pacemaker results in superior clinical outcomes. Methods The Pacemaker Selection in the Elderly study was a 30-month, single-blind, randomized, controlled comparison of ventricular pacing and dual-chamber pacing in 407 patients 65 years of age or older in 29 centers. Patients received a dual-chamber pacemaker that had been randomly programmed to either ventricular pacing or dual-chamber pacing. The primary end point was health-related quality of life as measured by the 36-item Medical Outcomes Study Short-Form General Health Survey. Results The average age of the patients was 76 years (range, 65 to 96), and 60 percent were men. Quality of life improved significantly after pacemake...
613 citations
TL;DR: The evolution of a clinically recognized syndrome, an analysis of possible mechanisms and clinical manifestations, and diagnostic approaches and their implications for management are discussed.
Abstract: The pacemaker syndrome is a complex of clinical signs and symptoms related to the adverse hemodynamic and electrophysiologic consequences of ventricular pacing in the absence of other causes. Neurologic symptoms or those suggesting low cardiac output or congestive heart failure, temporally related to the onset of ventricular pacing, are indicative of the pacemaker syndrome. The evolution of a clinically recognized syndrome, an analysis of possible mechanisms and clinical manifestations, and diagnostic approaches and their implications for management are discussed.
199 citations
TL;DR: The Mode Selection Trial (MOST) as mentioned in this paper is a single-blind study supported by the National Heart, Lung, and Blood Institute designed to enroll 2000 patients with SSS.
180 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 10 |
| 2020 | 8 |
| 2019 | 1 |
| 2018 | 4 |
| 2017 | 5 |
| 2016 | 4 |