About: Ovarian cancer is a research topic. Over the lifetime, 33789 publications have been published within this topic receiving 1031480 citations. The topic is also known as: malignant tumour of ovary & primary ovarian cancer.
TL;DR: Gemcitabine has some activity in heavily pretreated ovarian cancer patients and deserves further investigation in this malignancy, with uncomplicated neutropenia the main hematological toxicity.
TL;DR: Platelet lymphocyte ratio is shown for the first time that PLR is a novel independent prognostic marker in patients with ovarian cancer.
Abstract: Introduction
Ovarian cancer is associated with high mortality due to presentation at advanced stage and high recurrence following treatment with chemotherapy. Most of the prognostic variables in ovarian cancer, including stage and residual disease, are amenable for assessment only after surgery. Currently there are no established preoperative markers including, CA-125, that can predict overall survival in patients with ovarian cancer. The aim of our study was to evaluate the prognostic significance of the preoperative haematological markers platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) in patients with ovarian cancer.
TL;DR: The first spontaneous transformed syngeneic model of high-grade serous ovarian cancer was utilized for providing a new therapeutic opportunity and exosomal doxorubicin (exoDOX) is safer and more effective than free DOX.
TL;DR: Ovarian conservation until at least age 65 benefits long-term survival for women at average risk of ovarian cancer when undergoing hysterectomy for benign disease.