Topic
Osmophobia
About: Osmophobia is a research topic. Over the lifetime, 114 publications have been published within this topic receiving 2145 citations. The topic is also known as: olfactophobia.
Papers published on a yearly basis
Papers
TL;DR: The finding that exploding headache was impervious to extracranial BTX‐A injections is consistent with the prevailing view that migraine pain is mediated by intracranial innervation.
Abstract: Migraine headache is routinely managed using medications that abort attacks as they occur. An alternative approach to migraine management is based on prophylactic medications that reduce attack frequency. One approach has been based on local intramuscular injections of Botulinum Toxin Type A (BTX-A). Here, we explored for neurological markers that might distinguish migraine patients who benefit from BTX-A treatment (100 units divided into 21 injections sites across pericranial and neck muscles). Responders and non-responders to BTX-A treatment were compared prospectively (n = 27) and retrospectively (n = 36) for a host of neurological symptoms associated with their migraine. Data pooled from all 63 patients are summarized below. The number of migraine days per month dropped from 16.0 ± 1.7 before BTX-A to 0.8 ± 0.3 after BTX-A (down 95.3 ± 1.0%) in 39 responders, and remained unchanged (11.3 ± 1.9 vs. 11.7 ± 1.8) in 24 non-responders. The prevalence of aura, photophobia, phonophobia, osmophobia, nausea, and throbbing was similar between responders and non-responders. However, the two groups offered different accounts of their pain. Among non-responders, 92% described a buildup of pressure inside their head (exploding headache). Among responders, 74% perceived their head to be crushed, clamped or stubbed by external forces (imploding headache), and 13% attested to an eye-popping pain (ocular headache). The finding that exploding headache was impervious to extracranial BTX-A injections is consistent with the prevailing view that migraine pain is mediated by intracranial innervation. The amenability of imploding and ocular headaches to BTX-A treatment suggests that these types of migraine pain involve extracranial innervation as well.
134 citations
TL;DR: It is demonstrated that migraine pain is clearly related to nausea, but is also correlated with other associated migraine symptoms, and taste abnormality and osmophobia are better correlated with headache duration rather than headache intensity.
Abstract: This study explores the relationship of the pain of the migraine headache and the associated features of migraine Migraineurs (n=1025) (ICHD-2, 11-12 and 151) were evaluated retrospectively using a detailed database (daily unremitting excluded) Variables studied included headache intensity and duration, associated symptoms and pain characteristics Non-parametric correlations were used to evaluate relationships among variables Headache intensity correlated with nausea, vomiting, photophobia, phonophobia, dizziness (all P=0000), running of the nose/tearing of the eyes (P=0007), and osmophobia (P=0044), but not with diarrhoea or taste abnormality Headache duration correlated only with osmophobia (P=0002) and taste abnormality (P=0005) Throbbing, pressure and stabbing pain correlated with most of the associated symptoms Aching correlated only with taste abnormality This correlational study demonstrates that migraine pain is clearly related to nausea, but is also correlated with other associated migraine symptoms Taste abnormality and osmophobia are better correlated with headache duration rather than headache intensity
131 citations
TL;DR: The data support the view that commonly reported trigger factors of migraine are not so much independent precipitators of migraine pain, but that they are most likely just misinterpreted results of enhanced attention to certain stimuli mediated by typical premonitory symptoms of migrainePain.
Abstract: Certain environmental stimuli are frequently reported as typical triggers of migraine pain. Whether these so-called triggers are independent precipitators of migraine pain or mere symptoms of the premonitory phase of migraine remains to be elucidated. In this retrospective cohort study of 1010 migraine patients of a tertiary headache center we assessed the frequency of common trigger factors, premonitory symptoms and accompanying symptoms as well as basic headache characteristics and demographic data. Premonitory symptoms with an onset of 2 or more hours prior to the headache were present in 38.9% of migraine patients, the most frequent being a tense neck, phonophobia and difficulty concentrating. There was a clear overlap of certain trigger factors and the presence of corresponding premonitory symptoms: flickering or bright light as a trigger was associated with higher frequency of photophobia in the premonitory phase. The same applied to the presence of food craving and osmophobia in the premonitory phase and certain foods or odours as trigger factors. Our data thus support the view that commonly reported trigger factors of migraine are not so much independent precipitators of migraine pain, but that they are most likely just misinterpreted results of enhanced attention to certain stimuli mediated by typical premonitory symptoms of migraine pain.
122 citations
TL;DR: Osmophobia seems to be a peculiar symptom favouring the diagnosis of migraine (MoA and MA) in the differential diagnosis with ETTH, and appears structurally integrated into the migraine history of the patient.
Abstract: Intolerance to smell is often reported by migraine patients. This study evaluates osmophobia in connection with the diagnosis of migraine and episodic tension-type headache (ETTH). The characteristics of this symptom are also investigated. We recruited from our Headache Centre 1005 patients (772 female, 233 male; age 37 ± 11 years), of whom 677 were migraine without aura (MoA), 130 migraine with aura (MA) and 198 TTH. Patients with two or more forms of primary headache were excluded. Among migraine patients, 43.9% with MoA and 38.5% with MA reported osmophobia during the attacks; none of the 198 TTH patients suffered this symptom. Most frequently offending odours were scents (63.9%), food (55.2%) and cigarette smoke (54.8%). Osmophobia appears structurally integrated into the migraine history of the patient. It seems to be a peculiar symptom favouring the diagnosis of migraine (MoA and MA) in the differential diagnosis with ETTH.
94 citations
TL;DR: Osmophobia or hyperosmia featured in 25 of 50 migraineurs during the headache phase of their attacks, indicating support for a primary neural rather than a vascular pathogenesis of migraine.
Abstract: Osmophobia or hyperosmia featured in 25 of 50 migraineurs during the headache phase of their attacks. Pleasant or unpleasant odours could precipitate migraines in 11 patients in this series. Other sensory disturbances and precipitants were also studied. Neurological precipitation of attacks provides further support for a primary neural rather than a vascular pathogenesis of migraine.
91 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 11 |
| 2020 | 8 |
| 2019 | 5 |
| 2018 | 7 |
| 2017 | 7 |
| 2016 | 8 |