Topic
Onconephrology
About: Onconephrology is a research topic. Over the lifetime, 57 publications have been published within this topic receiving 2246 citations.
Papers
TL;DR: To show that local reduction of VEGF within the kidney is sufficient to trigger the pathogenesis of thrombotic microangiopathy, this work used conditional gene targeting to delete V EGF from renal podocytes in adult mice and resulted in a profound thromBotic glomerular injury.
Abstract: The glomerular microvasculature is particularly susceptible to injury in thrombotic microangiopathy, but the mechanisms by which this occurs are unclear. We report the cases of six patients who were treated with bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), in whom glomerular disease characteristic of thrombotic microangiopathy developed. To show that local reduction of VEGF within the kidney is sufficient to trigger the pathogenesis of thrombotic microangiopathy, we used conditional gene targeting to delete VEGF from renal podocytes in adult mice; this resulted in a profound thrombotic glomerular injury. These observations provide evidence that glomerular injury in patients who are treated with bevacizumab is probably due to direct targeting of VEGF by antiangiogenic therapy.
1,420 citations
TL;DR: CPI-induced AKI is a new entity that presents with clinical and histologic features similar to other causes of drug-induced acute tubulointerstitial nephritis, though with a longer latency period, and glucocorticoids appear to be a potentially effective treatment strategy.
583 citations
TL;DR: Risks of acute kidney injury is a common complication in cancer patients, particularly in patients with kidney cancer, liver cancer, or multiple myeloma, and risks were higher among patients with distant metastases at cancer diagnosis.
225 citations
Brigham and Women's Hospital1, University of Texas MD Anderson Cancer Center2, Cornell University3, Columbia University Medical Center4, Mayo Clinic5, Washington University in St. Louis6, Icahn School of Medicine at Mount Sinai7, University of Washington8, University of Miami9, Duke University10, Memorial Sloan Kettering Cancer Center11, University of California, Los Angeles12, Beth Israel Deaconess Medical Center13, University of South Florida14, University of Nebraska Medical Center15, Dartmouth–Hitchcock Medical Center16, University Health Network17, University of Alabama at Birmingham18, Harvard University19, Hofstra University20, Rega Institute for Medical Research21
TL;DR: In this paper, the authors conducted a multicenter retrospective study of 69 patients with a kidney transplant receiving ICIs between January 2010 and May 2020, and assessed the incidence, timing, and risk factors of acute graft rejection.
121 citations
TL;DR: This comprehensive review covers many of the critical topics in onconephrology, with a focus on acute kidney injury, chronic kidney disease, drug‐induced nephrotoxicity, kidney disease in stem cell transplantation, and electrolyte disorders in patients with cancer.
Abstract: Onconephrology is a new subspecialty of nephrology that recognizes the important intersections of kidney disease with cancer. This intersection takes many forms and includes drug-induced nephrotoxicity, electrolyte disorders, paraneoplastic glomerulonephritis, and the interactions of chronic kidney disease with cancer. Data clearly demonstrate that, when patients with cancer develop acute or chronic kidney disease, outcomes are inferior, and the promise of curative therapeutic regimens is lessened. This highlights the imperative for collaborative care between oncologists and nephrologists in recognizing and treating kidney disease in patients with cancer. In response to this need, specific training programs in onconephrology as well as dedicated onconephrology clinics have appeared. This comprehensive review covers many of the critical topics in onconephrology, with a focus on acute kidney injury, chronic kidney disease, drug-induced nephrotoxicity, kidney disease in stem cell transplantation, and electrolyte disorders in patients with cancer.
115 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 10 |
| 2020 | 14 |
| 2019 | 5 |
| 2018 | 3 |
| 2017 | 3 |
| 2016 | 6 |