Topic
Oncogene JUN
About: Oncogene JUN is a research topic. Over the lifetime, 18 publications have been published within this topic receiving 2773 citations.
Papers
TL;DR: The experimental results reported here indicate that the JUN oncoprotein is a sequence-specific transcriptional activator similar to AP-1, the product of the c-jun proto-oncogene.
Abstract: Proto-oncogenes encode proteins with three main sites of action: the cell-surface membrane, the cytoplasm and the nucleus. Although the exact biochemical function of most proto-oncogene products is not understood, several of them are known to be involved in signal transduction. A role in gene regulation through DNA binding has been suggested for a recently isolated member of the group of oncogenes acting at the nucleus, v-jun. The C-terminus of the putative v-jun-encoded protein is similar in sequence to the C-terminus of the yeast transcriptional activator GCN4 (refs 8, 9), which forms its minimal DNA-binding domain. GCN4 binds to specific sites whose consensus sequence is highly similar to the recognition sequence of the mammalian transcriptional activator AP-1 (refs 12, 13). Like GCN4, AP-1 binds to promoter elements of specific genes and activates their transcription. Because of the similarity between the recognition sites for GCN4 and AP-1, we examined the possibility that AP-1 could be the product of the c-jun proto-oncogene. The experimental results reported here indicate that the JUN oncoprotein is a sequence-specific transcriptional activator similar to AP-1.
932 citations
TL;DR: The amino acid sequence homology between GCN4 and jun gene products suggests that the jun protein may bind to DNA in a sequence-specific way and exert a regulatory function.
Abstract: The product of the recently described oncogene jun shows significant amino acid sequence homology with the GCN4 yeast transcriptional activator protein. The similarity is restricted to the 66 carboxyl-terminal amino acids, thought to be the DNA-binding domain of the GCN4 protein. In these alpha-helix-permissive regions of the jun and GCN4 products there is also a lesser but still significant amino acid resemblance to the fos protein and a marginal degree of similarity to myc proteins. The amino acid sequence homology between GCN4 and jun gene products suggests that the jun protein may bind to DNA in a sequence-specific way and exert a regulatory function.
272 citations
TL;DR: The identification of a MDV gene encoding a protein with homology to the leucine-zipper class of nuclear oncogenes is reported, which is one of the few genes that are highly expressed in MDV-induced T-cell tumors.
Abstract: Marek disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas within 3 weeks of infection. The short latency and polyclonal nature of MDV-induced tumors have suggested that the virus may encode one or more direct-acting oncogenes. To date, however, no MDV-specific tumor antigens or candidate transforming genes have been demonstrated. In this paper, we report the identification of a MDV gene encoding a protein with homology to the leucine-zipper class of nuclear oncogenes. It also contains a proline-rich domain characteristic of another class of transcription factors. This gene, designated meq, maps to the long repeat of MDV and is one of the few genes that are highly expressed in MDV-induced T-cell tumors. To our knowledge, a herpesvirus gene closely related to the fos/jun family of oncogenes has not been reported previously.
247 citations
TL;DR: It is shown that AP-1 activity is modulated by an inhibitory protein (IP-1), present both in the nucleus and cytoplasm of several cell types, and speculated that IP-1 might act as a transcriptional antioncogene.
214 citations
TL;DR: Jun is a transcription factor that can also induce oncogenic transformation and its DNA-binding domain is conserved from yeast to man and shows homology to several other transcriptional regulators.
113 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2013 | 1 |
| 2009 | 1 |
| 2007 | 1 |
| 2006 | 1 |
| 1999 | 1 |
| 1993 | 2 |