Topic
Oncocyte
About: Oncocyte is a research topic. Over the lifetime, 99 publications have been published within this topic receiving 1956 citations.
Papers published on a yearly basis
Papers
TL;DR: It is concluded that renal oncocytomas have a varied morphologic appearance and their pathologic diagnosis should be based on a constellation of architectural and cytologic features.
Abstract: We reviewed 954 primary nonurothelial epithelial renal neoplasms with primary resection at Memorial Sloan-Kettering Cancer Center between the years 1980 and 1995 and classified 70 cases (7%) as renal oncocytomas The study population was composed of 39 men and 31 women, and the mean age was 65 years (range 25 to 86 years) Fifty-six patients (80%) were asymptomatic at presentation, six (4%) had flank pain, six (4%) presented with a mass, and two (3%) had hematuria Sixty-one were treated with total or radical nephrectomy, nine with partial nephrectomy The right kidney was involved in 35 cases (50%), the left kidney in 32 (46%) Three cases (4%) were bilateral Sixty-one cases (87%) were unifocal, nine (13%) multifocal All the tumors were well circumscribed but unencapsulated Forty-five (64%) were described as brown or red, whereas the remainder were variously described as tan to yellow Central fibrosis or scar was described in 23 cases (33%), and gross areas of hemorrhage or cystic changes in 14 (20%) The mean size was 52 cm and median 50 cm (range 15 cm to 14 cm) Histologically, the tumors were characterized by a mixture of architectural patterns: compact cellular nests and acini embedded in a hyalinized, hypocellular stroma were present in 62 cases (89%), a solid nested architecture in 47 cases (67%), and a variable tubular component in 50 cases (71%) Small papillae, pseudopapillae, and intratubular epithelial tufts were seen in 19 cases (27%) Cytologically, the neoplasms also showed a mixture of cell types, the most common being the classic oncocyte, which consisted of round or polygonal cells with moderate to abundant granular, eosinophilic cytoplasm, and small round nuclei with evenly dispersed granular chromatin Small basophilic nucleoli were visible in many of these cells in all cases Thirty-one cases (44%) had a variable number of oncocytic cells with pyknotic nuclei and 20 (30%) contained clusters of small cells with a high nuclear/cytoplasmic ratio and dense hyperchromatic nuclei (so-called oncoblasts) Foci of tubules with clear cells embedded in a hyalinized stroma were present in six cases (9%) Cellular atypia was evident in 42 cases (60%) and was marked in 21 (30%) Eleven cases (16%) exhibited mitotic activity, albeit low No case had atypical mitoses or necrosis Twenty-two cases (31%) had areas of calcification within the hyalinized stroma, 12 (17%) had calcospherites, and three (4%) had osseous and myeloid metaplasia Vascular invasion was present in three cases (4%), and invasion of perinephric fat in 14 (20%) One patient presented with liver metastasis Fourteen cases (20%) were pT1, 42 (60%) pT2, and 14 (20%) pT3 After a mean follow-up of 58 months (range 1 to 181), 62 patients (89%) were alive with no evidence of tumor, six (9%) had died of other causes, one was alive with stable metastatic disease in the liver 58 months after diagnosis, and one died with metastatic disease to bone and liver We conclude that renal oncocytomas have a varied morphologic appearance and their pathologic diagnosis should be based on a constellation of architectural and cytologic features The overwhelming majority of cases behave in a benign fashion, although in rare instances they can metastasize The presence of atypical morphologic features do not alter the excellent prognosis associated with oncocytomas and do not predict an aggressive clinical course
330 citations
TL;DR: It is demonstrated that the size of a Hürthle cell neoplasm is predictive of malignancy, and definitive resection involving both thyroid lobes should be considered because of the higher probability ofmalignancy.
Abstract: OBJECTIVE: To determine if any preoperative or intraoperative factors can reliably predict malignancy in patients with Hurthle cell neoplasms. SUMMARY BACKGROUND DATA: Most experienced surgeons recommend total thyroidectomy for Hurthle cell carcinomas and reserve thyroid lobectomy for Hurthle cell adenomas. However, delineation between Hurthle cell adenoma versus carcinoma often cannot reliably be made either before or during surgery. METHODS: Medical records from 57 consecutive patients who underwent thyroid resections for Hurthle cell neoplasms between October 1984 and April 1995 at The Johns Hopkins Hospital were analyzed to determine if any factors were predictive of malignancy. RESULTS: Of the 57 patients with Hurthle cell neoplasms, 37 had adenomas and 20 had carcinomas, resulting in a 35% prevalence of malignancy. Patients with adenomas did not differ from those with carcinoma with respect to age, sex, or history of head and neck irradiation. However, patients with Hurthle cell carcinomas had significantly larger tumors (4.0 +/- 0.4 cm vs. 2.4 +/- 0.2 cm, p 4 cm), definitive resection involving both thyroid lobes should be considered because of the higher probability of malignancy.
160 citations
TL;DR: The incidence, histology, diagnosis and therapy of adrenal oncocytic neoplasms, a rare and mostly benign tumor, usually presents as an incidental, large adrenal mass; surgery is the mainstay of therapy, by means of laparoscopy which is now the most diffuse approach to adrenalectomy.
Abstract: Introduction: Oncocytic neoplasms as tumors arising in the adrenal glands are rare, usually considered as nonfunctional and benign. In the current literature, there are extremely limited reports of adrenal oncocytic neoplasms; as to date, only 147 cases have been described. The rarity of the event prompted this study which reviews and presents the inci- dence, histology, diagnosis and therapy of adrenal oncocyt- ic neoplasms. Materials and Methods: A review by system- atic literature search was done using the MEDLINE /Cochrane libraries from 1950 to date using the medical subject head- ings 'oncocytoma', 'adrenal gland', 'adrenal oncocytoma', 'adrenal oncocytic neoplasm' and 'adrenal oncocytic carci- noma'. Results: Adrenal oncocytic neoplasm is a rare dis- ease, usually incidentally detected because only 17% are functional adrenal masses. The typical oncocyte displays abundant granular eosinophilic cytoplasm, due to the ac- cumulation of mitochondria. Computed tomography and magnetic resonance imaging are not able to identify or dif- ferentiate benign and malignant oncocytic neoplasms. The mainstay of therapy is adrenalectomy, recently performed by laparoscopy. The prognosis is good for benign tumors, while adrenocortical oncocytic carcinoma has a poor surviv- al rate of only 5 years. Conclusions: Adrenal oncocytic neo-
143 citations
TL;DR: An oncocytoma of the submaxillary gland was examined and it was concluded that, regardless of cell type, an oncocyte should be defined by the ultrastructural characteristic of mitochondrial hyperplasia.
Abstract: An oncocytoma of the submaxillary gland was examined by light and electron microscopy. Two different types of oncocytes were seen. The most prevalent was the usual polyhedral, epithelial oncocyte. The second type of oncocyte has not previously been described, to our knowledge, and consisted of an elongated cell with myofibrils and mitochondrial hyperplasia, a myoepithelial oncocyte. It is concluded that, regardless of cell type, an oncocyte should be defined by the ultrastructural characteristic of mitochondrial hyperplasia. The fine structural features of the hyperplastic mitochondria suggest that they may be secondary to quantitative mitochondrial enzyme(s) deficiency.
75 citations
TL;DR: The oncocyte is a peculiar cell found in the aging parotid gland and a precise definition of oncocytic tumors is now available using histochemical and electron microscopic techniques.
Abstract: The oncocyte is a peculiar cell found in the aging parotid gland. A precise definition of oncocytic tumors in now available using histochemical and electron microscopic techinques. Oncocytic carcinomas are very rare; only a handful have been cited in the literature. This is the first description of the electron microscope features of oncocytic carcinomas we can find in the literature. The cells of these carcinomas are characterized by mitochondrial hyperplasia, pleomorphism and atypism. The cells contained few other subcellular organelles and no myofilaments or glycogen as previously described in benign oncocytomas. In addition to these electron microscopic features, the clinical presentation, treatment, and biologic course of these three cases of oncocytic carcinoma and two cases of benign oncocytoma will be presented.
73 citations
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| Year | Papers |
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| 2021 | 1 |
| 2020 | 2 |
| 2019 | 2 |
| 2018 | 1 |
| 2017 | 1 |
| 2016 | 2 |