TL;DR: This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors.
TL;DR: A genetic approach is developed to visualize axons from olfactory sensory neurons expressing a given odorant receptor, as they project to the Olfactory bulb, which provides direct support for a model in which a topographic map of receptor activation encodes odor quality in the ofactory bulb.
TL;DR: An electronic nose constructed using semiconductor transducers and incorporating design features suggested by the proposal can reproducibly discriminate between a wide variety of odours, and its properties show that discrimination in an olfactory system could be achieved without the use of highly specific receptors.
Abstract: Olfaction exhibits both high sensitivity for odours and high discrimination between them. We suggest that to make fine discriminations between complex odorant mixtures containing varying ratios of odorants without the necessity for highly specialized peripheral receptors, the olfactory systems makes use of feature detection using broadly tuned receptor cells organized in a convergent neurone pathway. As a test of this hypothesis we have constructed an electronic nose using semiconductor transducers and incorporating design features suggested by our proposal. We report here that this device can reproducibly discriminate between a wide variety of odours, and its properties show that discrimination in an olfactory system could be achieved without the use of highly specific receptors.
TL;DR: 'Amygdala' and 'amygdalar complex' are terms that now refer to a highly differentiated region near the temporal pole of the mammalian cerebral hemisphere, and cell groups within it appear to be differentiated parts of the traditional cortex, the claustrum, or the striatum.
TL;DR: In situ hybridization with five different receptor probes demonstrates that axons from neurons expressing a given receptor converge on one, or at most, a few glomeruli within the olfactory bulb, which supports a model in which exposure to a given odorant may result in the stimulation of a spatially restricted set ofglomeruli.