TL;DR: An investigation of the action of ODAP on glutamate metabolism in isolated brain mitochondria was undertaken and the results presented in this communication show brain degenerative effects in the brain.
TL;DR: Heterogeneity of the systems responsible for the metabolism of the injected bicarbonate is indicated, which would appear to involve the predominant part of the glutamate and glutamine labelled from this precursor and to be unaffected by the neuronal excitation effected by NMDA.
TL;DR: Glutamate and aspartate completely suppress the activity of horizontal cells but only partially affect the response of receptor cells to light, consistent with the interruption of a synaptically mediated process.
Abstract: Glutamate and aspartate completely suppress the activity of horizontal cells but only partially affect the response of receptor cells to light The changes observed in the receptor responses are consistent with the interruption of a synaptically mediated process rather than with a direct action on the receptor membrane