Topic
Netrin
About: Netrin is a research topic. Over the lifetime, 1046 publications have been published within this topic receiving 72012 citations. The topic is also known as: IPR001134 & Netrin.
Papers published on a yearly basis
Papers
TL;DR: Evidence is accumulating that these mechanisms act simultaneously and in a coordinated manner to direct pathfinding and that they are mediated by mechanistically and evolutionarily conserved ligand-receptor systems.
Abstract: Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is accumulating that these mechanisms act simultaneously and in a coordinated manner to direct pathfinding and that they are mediated by mechanistically and evolutionarily conserved ligand-receptor systems.
3,319 citations
TL;DR: This work has shown that a relatively small number of guidance factors can be used to generate intricate patterns of neuronal wiring through signaling pathways still only poorly understood.
Abstract: Axons are guided along specific pathways by attractive and repulsive cues in the extracellular environment. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules, including netrins, Slits, semaphorins, and ephrins. Guidance cues steer axons by regulating cytoskeletal dynamics in the growth cone through signaling pathways that are still only poorly understood. Elaborate regulatory mechanisms ensure that a given cue elicits the right response from the right axons at the right time but is otherwise ignored. With such regulatory mechanisms in place, a relatively small number of guidance factors can be used to generate intricate patterns of neuronal wiring.
1,436 citations
TL;DR: It is shown that netrin-1 is a chemotropic factor expressed by floor plate cells and suggested that the two netrin proteins guide commissural axons in the developing spinal cord.
1,389 citations
TL;DR: In this article, the authors have purified from embryonic chick brain two proteins, Netrin-1 and netrin-2, that each possess commissural axon outgrowth-promoting activity and also identified a distinct activity that potentiates their effects.
1,384 citations
TL;DR: Results establish netrin-1 as a guidance cue that likely collaborates with other diffusible cues to guide axons in vivo and evidence is provided for a distinct trochlear axon chemorepellent produced by floor plate cells.
1,355 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 41 |
| 2024 | 80 |
| 2023 | 90 |
| 2022 | 72 |
| 2021 | 35 |
| 2020 | 46 |