Showing papers on "Naja published in 1986"
TL;DR: It is concluded that anticholinesterases are beneficial in the management of neurotoxic envenoming by Asian cobras (Naja naja), and a test of edrophonium is recommended in any patient with signs of neurot Toxic Envenoming after snakebite.
Abstract: To study the ability of anticholinesterase drugs to reverse the potentially fatal paralytic effects of cobra venom, we conducted a placebo-controlled, double-blind crossover trial of intravenous edrophonium (Tensilon) in 10 adults with neurotoxic envenoming caused by bites of the Philippine cobra (Naja naja philippinensis). There was significantly more improvement in ptosis and endurance of upward gaze after edrophonium than after placebo. Five minutes after injection, the mean difference (+/- SD) in the percentage of the iris that was uncovered was 39 +/- 5.47 (70 vs. 31 percent; P less than 0.01), and the mean difference in the number of seconds of upward gaze was 33.1 +/- 9.29 (39.7 vs. 6.6 seconds; P less than 0.01). The expiratory and inspiratory pressures, forced vital capacity, and ability to cough, speak, and swallow also improved after edrophonium. In both the patients who were studied electromyographically, pretreatment and postplacebo responses were typical of myasthenia gravis and became normal after edrophonium. We conclude that anticholinesterases are beneficial in the management of neurotoxic envenoming by Asian cobras (Naja naja), and we recommended a test of edrophonium in any patient with signs of neurotoxic envenoming after snakebite.
110 citations
Journal Article•
TL;DR: The results of this experiment indicate that large and heavy snakes provide more venom extract as compared to snakes of medium and small sizes and weight.
Abstract: The results of this experiment indicate that large and heavy snakes provide more venom extract as compared to snakes of medium and small sizes and weight. The large sized snakes are tougher and remain healthy throughout experimental period as compared to snakes of lesser size and weight. For the purpose of collection of crude venom for production of anti snake venom, large and heavy snakes are preferred. If properly maintained, these snakes would survive for at least 2-21/2 months under standard captive conditions. After initial five weekly extraction of freshly caught snakes fortnightly subsequent extractions are proposed for obtaining reasonable quantity of venom extract(JPMA36:278, 1986).
3 citations
Journal Article•
2 citations
1 Jan 1986
TL;DR: An immobilized form of the enzyme is prepared and its kinetic properties are studied and it is shown that phospholipase A2 acts as a model system for the study of enzymes of lipid metabolism.
Abstract: Phospholipase A2 is perhaps the most well-studied and well-characterized enzyme of phospholipid breakdown and as such serves as a paradigm or model system for the study of enzymes of lipid metabolism (Review: 1). Over the years, our laboratory has used a variety of approaches to study the phospholipase A2 from the venom of the Indian cobra (Naja naja naja) as summarized elsewere (2). Among these approaches, we (3) prepared an immobilized form of the enzyme and studied its kinetic properties; this study was published in 1978.
1 citations
TL;DR: It is concluded that the venoms have one or more component(s) causing histamine release which masks the relaxation caused by another component(S) of the venom.