Showing papers on "Naja published in 1972"
Journal Article•
TL;DR: Although their pharmacological actions are quite different, the amino acid sequences of cytotoxins were similar to those of cobra neurotoxins.
Abstract: Homogeneous cytotoxins I and II with high cytotoxicity to Yoshida sarcoma and hepatoma cells were isolated from the venom of the Indian cobra Naja naja. The amino acid sequence of cytotoxin II was determined with the aid of tryptic digestion and cleavage by cyanogen bromide. Although their pharmacological actions are quite different, the amino acid sequences of cytotoxins were similar to those of cobra neurotoxins.
44 citations
TL;DR: Sera of 22 species of colubrid snakes were studied by immunoelectrophoresis using antisera against serum proteins of Coluber constrictor, Elaphe vulpina, Natrix sipedon, Naja naja and Crotalus horridus to develop the preparations.
Abstract: Sera of 22 species of colubrid snakes were studied by immunoelectrophoresis using antisera against serum proteins of Coluber constrictor, Elaphe vulpina, Natrix sipedon, Naja naja and Crotalus horridus to develop the preparations. Development of a snake serum with its homologous antiserum gives a pattern of seven or eight precipitin arcs. Some of these represent components widely shared among snakes, while others are more or less specific for closely related taxa. Two serological groups can be distinguished in our material. One consists of Elaphe (3 sp.), Lampropeltis (2 sp.) and Pituophis melanoleucus. The other group consists of Natrix (4 sp.), Thamnophis (2 sp.), and Regina septemvittata. Serologically these groups are as distinct from each other as they are from Naja and Crotalus. Coluber constrictor is somewhat intermediate between the two but closer to Elaphe. Three Old World colubrids, Coluber jugularis, C. ravergieri and Spalerosophis diadema, are serologically intermediate between Coluber constrictor and Elaphe. Malpolon monspessulanus and Psammophis schokari are also intermediate but slightly closer to Coluber. The affinities of Trimorphodon biscutatus are more nearly with Elaphe than with Coluber or Natrix. Leptodeira maculata and Heterodon platyrhinos do not fit the above groups nor do they appear to be closely related to one another.
17 citations
TL;DR: It appears that Naja naja, Dendroaspis viridis, Echis carinatus, Vipera berus and Vipera aspis venoms, used as immunizing antigens, contain proteins, the chemical constitution of which is close to that of the salivary gland antIGens of the four Colubridae.
11 citations
TL;DR: Antibodies were prepared by hyperimmunizing rabbits with Naja naja, Bungarus fasciatus, Agkistrodon piscivorus and Apis mellifera (honeybee) venoms and it has been shown that several of the esterases present in Naja species are immunologically identical.
10 citations
Journal Article•
1 citations
TL;DR: The principal neurotoxins of five cobras have been purified by ion-exchange chromatography on Bio-Rex 70 in volatile ammonium acetate buffers, followed by gel Chromatography on Sephadex G-50.