Topic
NAD binding
About: NAD binding is a research topic. Over the lifetime, 211 publications have been published within this topic receiving 8504 citations.
Papers published on a yearly basis
Papers
TL;DR: The plant epimerase undergoes a complex regulation and could control the carbon flux into the vitamin C pathway in response to the redox state of the cell, stress conditions, and GDP-sugar demand for the cell wall/glycoprotein biosynthesis.
405 citations
TL;DR: The direct demonstration of AREspecific binding protein activity localized to the NAD+-binding region of GAPDH supports the general concept that enzymes containing this domain may exhibit specific RNA binding activity and play additional roles in nucleic acid metabolism.
378 citations
TL;DR: Two crystal structures of a SIR2 homolog from Archaeoglobus fulgidus complexed with NAD have been determined and provide important insights into the catalytic mechanism of NAD-dependent protein deacetylation by this family of enzymes.
336 citations
TL;DR: Sequence comparisons of the class 3 ALDH with other ALDHs indicate a similar polypeptide fold, novel NAD-binding mode and catalytic site for this family, and a mechanism for enzymatic specificity and activity is postulated.
Abstract: The first structure of an aldehyde dehydrogenase (ALDH) is described at 2.6 A resolution. Each subunit of the dimeric enzyme contains an NAD-binding domain, a catalytic domain and a bridging domain. At the interface of these domains is a 15 A long funnel-shaped passage with a 6 × 12 A opening leading to a putative catalytic pocket. A new mode of NAD binding, which differs substantially from the classic β-α-β binding mode associated with the ‘Rossmann fold’, is observed which we term the β-α,β mode. Sequence comparisons of the class 3 ALDH with other ALDHs indicate a similar polypeptide fold, novel NAD-binding mode and catalytic site for this family. A mechanism for enzymatic specificity and activity is postulated.
318 citations
TL;DR: The crystal structure of lobster d -glyceraldehyde-3-phosphate dehydrogenase has been analyzed and it is shown that the amino acids in the active center region and involved in subunit-subunit contacts are more highly conserved than other residues.
250 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 5 |
| 2020 | 3 |
| 2019 | 4 |
| 2018 | 3 |
| 2017 | 6 |
| 2016 | 1 |