About: Myosarcoma is a research topic. Over the lifetime, 121 publications have been published within this topic receiving 2141 citations. The topic is also known as: Myosarcoma (morphologic abnormality) & malignant neoplasm of muscle, NOS.
TL;DR: A brief review of the literature and observations in the series reported here confirm those impressions that this lesion of the digestive tract is not so rare as commonly thought.
Abstract: SURGICAL interest in gastrointestinal lymphoma obviously is limited to the solitary tumor amenable to extirpation. The prognosis in such a case is good—even better than that of gastrointestinal carcinoma treated at an early stage. This lesion of the digestive tract is not so rare as commonly thought. Singleton and Moore's collection of reports of gastrointestinal lymphosarcoma up to 1949 lists 563 cases. Its differential diagnosis is difficult. Its pathologic classification has been controversial. A brief review of the literature and observations in the series reported here confirm these impressions. Fourteen cases of malignant lymphoma of the gastrointestinal tract have been recorded at Cedars of Lebanon Hospital, Los Angeles, between January, 1942, and January, 1952, 9 of which were in the stomach: 7 lymphosarcomas, in 1 of which there was coexistant myosarcoma; 1 reticulum cell sarcoma, and 1 Hodgkin's disease. The other five were lymphosarcomas of the ileum, of the
TL;DR: In this paper, a series of 43 cases of uterine leiomyosarcoma was reviewed and the overall 5-year survival was 73% with premenopausal status of the patient, confinement of the tumor within a myoma, the low mitotic count (less than four mitotic figures in any one high power field or less than four figures per 10 high power fields), absence of necrosis, and the presence of hyalinization in the adjacent tissue suggesting confinement.
TL;DR: The clinical course was benign in all but one patient in whom a recurrence developed and metastases to the regional lymph nodes appeared 7 years after the initial excision, and it is suggested that the recurrence per se might be of prognostic importance.
Abstract: A retrospective study of 57 patients with atypical fibroxanthoma of the skin is presented. The light microscopy is described and the differential diagnosis is discussed. Most of the atypical fibroxanthomas (32 out of 57 cases) were originally diagnosed as soft tissue sarcomas, e.g. fibrosarcoma, dermatofibrosarcoma, neurofibrosarcoma, myosarcoma and unspecified sarcoma. The tumour occurred chiefly in middle-aged and elderly patients; three patients were 15 years old or younger. The median age was 73 years in patients in whom the tumour occurred in the head and neck, and 34 years in patients in whom the tumour developed on the extremities and trunk. The sex ratio (male to female) was almost equal. Follow-up information about 43 patients was available. The follow-up period ranged from 1 year to 25 years with a median of 9 years. Eight patients died from intercurrent disease; all the other 35 patients are alive and well. The clinical course was benign in all but one patient in whom a recurrence developed and metastases to the regional lymph nodes appeared 7 years after the initial excision. The tumour in this case did not differ histologically from the other atypical fibroxanthomas with respect to cellularity, cellular and nuclear atypia or mitotic activity. It is suggested that the recurrence per se might be of prognostic importance.
TL;DR: It is one of the paradoxes of medical progress that the trained surgeons and pathologists of today have as much trouble distinguishing between certainLeiomyomas and leiomyosarcomas as had their nineteenth century counterparts.
TL;DR: A previous report of a leiomyosarcoma of the nasopharynx cannot be found in the medical literature, and the Atlas of Otolaryngic Pathology from the Armed Forces Institute of Pathology does not list this tumor.
Abstract: A previous report of a leiomyosarcoma of the nasopharynx cannot be found in the medical literature. Geschickter, in classifying sarcomas of the nasopharynx, listed two cases as myosarcomas. 1 One of these was a rhabdomyosarcoma, and he has illustrated this tumor. The second case, which is listed as being myosarcoma, has no further explanation. Nonepithelial malignant tumors or malignant connective tissue tumors are exceedingly rare. Stout collected all the nasopharyngeal tumors up to 1941, and leiomyosarcoma is not mentioned. 2 The Atlas of Otolaryngic Pathology from the Armed Forces Institute of Pathology does not list this tumor. 3 The only smooth muscle normally found in the nasopharynx is in the structure of the blood-vessel walls. Boyd feels the muscular walls of blood vessels are immune to myoma formation. 4 This is difficult to understand in that myomatous tumors have been found in areas of the body which are normally devoid