Topic
MW polyomavirus
About: MW polyomavirus is a research topic. Over the lifetime, 5 publications have been published within this topic receiving 230 citations. The topic is also known as: Malawi polyomavirus & MWPyV.
Papers
TL;DR: A novel polyomavirus present in multiple human stool samples and predicted to encode the large T antigen and small T antigen early proteins and the VP1, VP2, and VP3 structural proteins is discovered.
Abstract: We have discovered a novel polyomavirus present in multiple human stool samples. The virus was initially identified by shotgun pyrosequencing of DNA purified from virus-like particles isolated from a stool sample collected from a healthy child from Malawi. We subsequently sequenced the virus' 4,927-bp genome, which has been provisionally named MW polyomavirus (MWPyV). The virus has genomic features characteristic of the family Polyomaviridae but is highly divergent from other members of this family. It is predicted to encode the large T antigen and small T antigen early proteins and the VP1, VP2, and VP3 structural proteins. A real-time PCR assay was designed and used to screen 514 stool samples from children with diarrhea in St. Louis, MO; 12 specimens were positive for MWPyV. Comparison of the whole-genome sequences of the index Malawi case and one St. Louis case demonstrated that the two strains of MWPyV varied by 5.3% at the nucleotide level. The number of polyomaviruses found in the human body continues to grow, raising the question of how many more species have yet to be identified and what roles they play in humans with and without manifest disease.
205 citations
TL;DR: This data provides new evidence for the hypothesis that the lymphoid system may play a role in HPyV infection and persistence and needs to be defined to define their role in tonsillar disease in the future.
23 citations
TL;DR: The presence of PyV DNA in Dutch blood donations was determined to study the possibility that blood components transmit PyVs, and to study this possibility, as a first step.
22 citations
TL;DR: The results of phylogenetic analysis support the hypothesis that STLPyV is geographically widespread and the prevalence of STL polyomavirus in Chinese children is reported, and whole genome sequences of ST LPyV strains isolated in China are obtained.
17 citations
1 Jan 2012
TL;DR: Comparative genomic analysis focuses on primate polyomaviruses, and two specific genomic alterations are shown for Merkel cellpolyomavirus and Trichodysplasia spinulosa-associated polyomvirus that may indicate a mechanism for primate host-switching for these two human polyomAViruses.
Abstract: Phylogenetic analysis of the mammalian and avian polyomaviruses was performed using the most complete set of publicly available polyomavirus genome sequences to date, including the newly discovered MW polyomavirus. There is no evidence for host-switching between mammalian and avian polyomaviruses, but there is extensive evidence for host-switching among mammalian polyomaviruses. Comparative genomic analysis focuses on primate polyomaviruses, and two specific genomic alterations are shown for Merkel cell polyomavirus and Trichodysplasia spinulosa-associated polyomavirus that may indicate a mechanism for primate host-switching for these two human polyomaviruses.
6 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2019 | 1 |
| 2016 | 1 |
| 2015 | 1 |
| 2012 | 2 |