MSH4

TL;DR: It is found that during meiosis in Saccharomyces cerevisiae, noncrossover heteroduplex products are formed at the same time as Holliday junction intermediates, and crossovers appear later, when these intermediates are resolved.

TL;DR: A null mutation is generated in the Dmc1 gene in mice and it is shown that homozygous mutant males and females are sterile with arrest of gametogenesis in the first meiotic prophase.

TL;DR: The different phenotypes of the three types of mutant mice suggest that these three genes may have independent functions in mammalian meiosis.

TL;DR: It is demonstrated here that branched DNA molecules containing information from both parental chromosomes occur in vivo at loci where meiosis-specific double-stranded breaks occur, and results strongly suggest that joint molecules are double Holliday junctions.