Topic
Morpholine
About: Morpholine is a research topic. Over the lifetime, 5411 publications have been published within this topic receiving 51063 citations. The topic is also known as: diethylene imidoxide & diethylene oximide.
Papers published on a yearly basis
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Papers
TL;DR: The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments) dimethylamine was blocked by ascorbic acid.
Abstract: The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments) dimethylamine was blocked by ascorbic acid. The extent of blocking depended on the compound nitrosated and on the experimental conditions. Urea and ammonium sulfamate were less effective as blocking agents. The possibility of in vivo formation of carcinogenic N-nitroso compounds from drugs could be lessened by the combination of such drugs with the ascorbic acid.
520 citations
TL;DR: In this article, the conductimetric stopped-flow technique was used for the reaction of carbon dioxide in aqueous solution with the primary amines 2-methoxyethylamine, 2-aminoethanol, 3-aminopropan-1-ol, 2.5amino-propane-2-(hydroxymethyl) propane-1,3-diol, 2,2,6,6-tetramethylpiperidin-4, and morpholine.
Abstract: Rate constants, ΔH‡ and ΔS‡ have been measured by the conductimetric stopped-flow technique for the reaction of carbon dioxide in aqueous solution with the primary amines 2-methoxyethylamine, 2-aminoethanol, 3-aminopropan-1-ol, 2-aminopropan-2-ol, DL-aminopropan-2-ol and the secondary amines 1,1′-iminodipropan-2-ol, 2-amino-2-(hydroxymethyl) propane-1,3-diol, 2,2′-iminodiethanol, 2,2,6,6-tetramethylpiperidin-4-ol, and morpholine. The observed first-order rate constants fit the equation kobs=kAM[R2NH]2+kW[R2NH][H2O]. The much-quoted Danckwerts mechanism is shown to be unlikely.
365 citations
TL;DR: A catalytic system for the mild amination of aryl chlorides is described, which consists of a Pd(0) precursor and a dihydroimidazoline carbene ligand generated in situ from its protonated tetrafluoroborate salt.
296 citations
TL;DR: In this article, β-Cyanoethyl monochlorophosphoamidites of the secondary amines N, N-dmethylamine, N,N-diisopropylamine and morpholine have been prepared which showed quantitative phosphitylation of the protected deoxynucleosides.
296 citations
TL;DR: Preliminary mechanistic studies showed that the reaction occurred by direct, irreversible, anti-Markovnikov hydroamination and that the mechanism of the ruthenium-Catalyzed hydroamination is likely to be distinct from that of the recently reported rhodium-catalyzed reaction.
Abstract: The transition metal-catalyzed anti-Markovnikov hydroamination of unactivated vinylarenes with a rhodium complex of DPEphos is reported The reaction of electron−neutral or electron-rich vinylarenes with a variety of secondary amines in the presence of catalyst forms the products from anti-Markovnikov hydroamination in high yields Reactions of morpholine, N-phenylpiperazine, N-Boc-piperazine, piperidine, 2,5-dimethylmorpholine, and perhydroisoquinoline reacted with styrene to form the amine product in 51−71% yield Reactions of a variety of vinylarenes with morpholine generated amine as the major product Reactions of morpholine with electron-poor vinylarenes gave lower amine:enamine ratios than reactions of electron-rich vinylarenes at the same concentration of vinylarene, but conditions were developed with lower concentrations of electron-poor vinylarene to maintain formation of the amine as the major product Reactions of dimethylamine with vinylarenes were fast and formed amine as the major product
237 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 42 |
| 2024 | 89 |
| 2023 | 119 |
| 2022 | 193 |
| 2021 | 95 |
| 2020 | 142 |