Modalities

Abstract: Mutual information is proposed as an information measure for evaluating image fusion performance. The proposed measure represents how much information is obtained from the input images. No assumption is made regarding the nature of the relation between the intensities in both input modalities. The results show that the measure is meaningful and explicit.

Abstract: In various disciplines, information about the same phenomenon can be acquired from different types of detectors, at different conditions, in multiple experiments or subjects, among others. We use the term “modality” for each such acquisition framework. Due to the rich characteristics of natural phenomena, it is rare that a single modality provides complete knowledge of the phenomenon of interest. The increasing availability of several modalities reporting on the same system introduces new degrees of freedom, which raise questions beyond those related to exploiting each modality separately. As we argue, many of these questions, or “challenges,” are common to multiple domains. This paper deals with two key issues: “why we need data fusion” and “how we perform it.” The first issue is motivated by numerous examples in science and technology, followed by a mathematical framework that showcases some of the benefits that data fusion provides. In order to address the second issue, “diversity” is introduced as a key concept, and a number of data-driven solutions based on matrix and tensor decompositions are discussed, emphasizing how they account for diversity across the data sets. The aim of this paper is to provide the reader, regardless of his or her community of origin, with a taste of the vastness of the field, the prospects, and the opportunities that it holds.

Abstract: The exceptionally rapid development of highly flexible, reusable artificial intelligence (AI) models is likely to usher in newfound capabilities in medicine. We propose a new paradigm for medical AI, which we refer to as generalist medical AI (GMAI). GMAI models will be capable of carrying out a diverse set of tasks using very little or no task-specific labelled data. Built through self-supervision on large, diverse datasets, GMAI will flexibly interpret different combinations of medical modalities, including data from imaging, electronic health records, laboratory results, genomics, graphs or medical text. Models will in turn produce expressive outputs such as free-text explanations, spoken recommendations or image annotations that demonstrate advanced medical reasoning abilities. Here we identify a set of high-impact potential applications for GMAI and lay out specific technical capabilities and training datasets necessary to enable them. We expect that GMAI-enabled applications will challenge current strategies for regulating and validating AI devices for medicine and will shift practices associated with the collection of large medical datasets. This review discusses generalist medical artificial intelligence, identifying potential applications and setting out specific technical capabilities and training datasets necessary to enable them, as well as highlighting challenges to its implementation.