Topic
Mitracarpus
About: Mitracarpus is a research topic. Over the lifetime, 57 publications have been published within this topic receiving 557 citations.
Papers published on a yearly basis
Papers
1 Jan 1994
TL;DR: Results from preliminary investigations on leaf extracts of Mitracarpus scaber establish its acclaimed potency as an antiinflammatory and antimicrobial agent and help to explain the rationale for the folkloric use of the plant in treating inflammatory disorders and microbial infections.
Abstract: Preliminary investigations were carried out on leaf extracts of Mitracarpus scaber with the goal of establishing its acclaimed potency as an antiinflammatory and antimicrobial agent. Petroleum-ether and methanol extracts were studied. In rats, the extracts progressively reduced fresh egg albuminin-induced edema of the hind paw. There was a dose-related and sustained inhibition of increase in paw circumference caused by subplantar injection of the phlogistic agent. The petroleum ether extract showed a more pronounced effect. In vitro, the extracts caused marked inhibition against some strains of laboratory microorganisms, the order of sensitivity being Pseudomonas aeruginosa> Kleb-sialla pneumoniao>Staphylococcus aureus> Escherichia coli. The extracts also inhibited the growth of Candida albicans. These results help to explain the rationale for the folkloric use of the plant in treating inflammatory disorders and microbial infections.
80 citations
TL;DR: Three new species of Mitracarpus Zucc from Brazil, belonging to the Rubiaceae family, are described, illustrated and compared to related taxa.
Abstract: Cabral, E. L., S. V. Sobrado & E. B. Souza (2013). Three new species of Mitracarpus Zucc. (Rubiaceae) from Brazil. Candollea 68: 139–146. In English, English and French abstracts. Three new species of Mitracarpus Zucc. (Rubiaceae), Mitracarpus carajasensis E. L. Cabral, Sobrado & E. B. Souza, Mitracarpus federalensis E. L. Cabral, Sobrado & E. B. Souza and Mitracarpus fernandesii E. L. Cabral, Sobrado & E. B. Souza, from Brazil, are described, illustrated and compared to related taxa.
51 citations
TL;DR: The methanolic extract and isolated constituents of Mitracarpus scaber Zucc have been reported to exhibit hepatoprotective, antibacterial and antimycotic activities and should be suitable for inclusion in the proposed Pharmacopoeia of Nigerian Medicinal plants.
Abstract: Purpose: The methanolic extract and isolated constituents of Mitracarpus scaber Zucc have been reported to exhibit hepatoprotective, antibacterial and antimycotic activities. Establishment of Pharmacognostic profile of the leaves will assist in standardization for quality, purity and sample identification.
Method: Evaluation of the fresh, powdered and anatomical sections of the leaves were carried out to determine the macromorphological, micromorphological, chemomicroscopic, numerical and phytochemical profiles.
Results: Macro - and microscopical studies indicated presence of simple leaf whorled arrangement, an entire margin with lanceolate shape, acute apex and base, parallel venation, thin and wavy anticlinal walls with numerous calcium oxalate crystals. Stomata arrangement was anomocytic with numerous covering trichomes on both surfaces. Chemomicroscopic characters present include lignin, starch, cellulose, mucilage and calcium oxalate crystals while phytochemical evaluation revealed the presence of alkaloids, tannins, cardiac glycosides and saponins. The investigations also included numerical and quantitative leaf microscopy.
Conclusion: These findings should be suitable for inclusion in the proposed Pharmacopoeia of Nigerian Medicinal plants.
Keywords : Mitracarpus scaber, Pharmacognostic evaluation, Pharmacopoeia. Tropical Journal of Pharmaceutical Research Vol. 6 (4) 2007: pp. 849-853
41 citations
TL;DR: The effect of Mitracarpus scaber on carbon tetrachloride‐induced acute liver damage in the rat has been evaluated and it is shown that scaber acts as a ‘spatially aggregating force’ to cause liver damage.
Abstract: The effect of Mitracarpus scaber on carbon tetrachloride-induced acute liver damage in the rat has been evaluated.
Results showed that treatment with Mitracarpus scaber decoction resulted in significant hepatoprotection against CCl4-induced liver injury both in-vivo and in-vitro. In-vivo, Mitracarpus scaber pretreatment reduced levels of serum glutamate-oxalate-transaminase (P 93%) survival rate for the CCl4-intoxicated hepatocytes as demonstrated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Moreover, as in the in-vitro assay, Mitracarpus scaber had radical-scavenging properties, shown by its reaction with the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical (EC50, the extract concentration resulting in a 50% reduction in the absorbance of DPPH blank solution, = 41.64 ± 1.5 μg mL−1).
The results of this study showed that Mitracarpus scaber had antihepatotoxic potential, a finding which supports the validity of traditional usage of this drug in Mali for the treatment of liver diseases.
35 citations
TL;DR: The in vivo antiplasmodial activity of Chrozophora extracts was determined by both the oral and the intraperitoneal ways, and could justify the traditional use of this plant in malaria treatment.
32 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 4 |
| 2020 | 3 |
| 2019 | 3 |
| 2018 | 1 |
| 2017 | 1 |
| 2016 | 1 |