Topic
Mitotic checkpoint complex
About: Mitotic checkpoint complex is a research topic. Over the lifetime, 221 publications have been published within this topic receiving 30549 citations.
Papers published on a yearly basis
Papers
TL;DR: Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores — structures that mediate the binding of spindle microtubules to chromosomes in mitosis.
Abstract: The spindle-assembly checkpoint is a safety device that monitors the attachment of spindle microtubules to kinetochores and ensures the fidelity of chromosome segregation in mitosis. Molecular studies are finally starting to reveal the mechanisms of checkpoint activation and inactivation.
2,390 citations
TL;DR: Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.
Abstract: The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.
1,384 citations
TL;DR: The role of feedback controls in coordinating events in the cell cycle is discussed and the properties of mad mutants indicate that they are defective in the feedback control over the exit from mitosis are discussed.
1,316 citations
TL;DR: Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy.
Abstract: Abnormal chromosome content — also known as aneuploidy — is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycle progression through mitosis until all chromosomes have successfully made spindle-microtubule attachments. Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy.
1,287 citations
TL;DR: Efforts to understand the nature and specification of the centromere have demonstrated that this central element for ensuring inheritance is itself epigenetically determined.
1,035 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 13 |
| 2020 | 8 |
| 2019 | 8 |
| 2018 | 16 |
| 2017 | 15 |
| 2016 | 19 |