Topic
Mink
About: Mink is a research topic. Over the lifetime, 3504 publications have been published within this topic receiving 65407 citations. The topic is also known as: little mink & great mink.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: KVLQT1 is the subunit that coassembles with minK to form IKS channels and IKS dysfunction is a cause of cardiac arrhythmia, and is shown to encode a K+ channel with biophysical properties unlike other known cardiac currents.
Abstract: THE slowly activating delayed-rectifier K+ current, IKS, modulates the repolarization of cardiac action potentials. The molecular structure of the IKS channel is not known, but physiological data indicate that one component of theIKSchannel is minK (refs 1–6), a 130-amino-acid protein with a single putative transmembrane domain7. The size and structure of this protein is such that it is unlikely that minK alone forms functional channels8,9. We have previously used positional cloning techniques to define a new putative K+-channel gene, KVLQT110. Mutations in this gene cause long-QT syndrome, an inherited disorder that increases the risk of sudden death from cardiac arrhythmias. Here we show that KVLQT1 encodes a K+ channel with biophysical properties unlike other known cardiac currents. We considered that KVLQT1 might coassemble with another subunit to form func-tional channels in cardiac myocytes. Coexpression of KVLQT1 with minK induced a current that was almost identical to cardiac IKS. Therefore, KVLQT1 is the subunit that coassembles with minK to form IKS channels and IKS dysfunction is a cause of cardiac arrhythmia.
1,795 citations
TL;DR: The SARS-CoV-2 virus was initially introduced by humans and has since evolved, most likely reflecting widespread circulation among mink in the beginning of the infection period, several weeks before detection.
Abstract: Animal experiments have shown that nonhuman primates, cats, ferrets, hamsters, rabbits, and bats can be infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition, SARS-CoV-2 RNA has been detected in felids, mink, and dogs in the field. Here, we describe an in-depth investigation using whole-genome sequencing of outbreaks on 16 mink farms and the humans living or working on these farms. We conclude that the virus was initially introduced by humans and has since evolved, most likely reflecting widespread circulation among mink in the beginning of the infection period, several weeks before detection. Despite enhanced biosecurity, early warning surveillance, and immediate culling of animals in affected farms, transmission occurred between mink farms in three large transmission clusters with unknown modes of transmission. Of the tested mink farm residents, employees, and/or individuals with whom they had been in contact, 68% had evidence of SARS-CoV-2 infection. Individuals for which whole genomes were available were shown to have been infected with strains with an animal sequence signature, providing evidence of animal-to-human transmission of SARS-CoV-2 within mink farms.
1,113 citations
TL;DR: Variations in mink-derived viral genomes showed between-mink transmission and no infection link between the farms, and inhalable dust contained viral RNA, indicating possible exposure of workers.
Abstract: Respiratory disease and increased mortality occurred in minks on two farms in the Netherlands, with interstitial pneumonia and SARS-CoV-2 RNA in organ and swab samples. On both farms, at least one worker had coronavirus disease-associated symptoms before the outbreak. Variations in mink-derived viral genomes showed between-mink transmission and no infection link between the farms. Inhalable dust contained viral RNA, indicating possible exposure of workers. One worker is assumed to have attracted the virus from mink.
734 citations
TL;DR: Mink may thrive in captivity but they miss having water to romp about in, so why not keep them in the wild?
Abstract: Captive animals may suffer if strongly motivated to perform activities that their housing does not allow. We investigated this experimentally for caged mink, and found that they would pay high costs to perform a range of natural behaviours, and release cortisol if their most preferred activity, swimming, was prevented.
Investigates the effect of limitations on caged mink. Popularity of fur farming; Research into the possible deprivation of mink, which result in their frustration; Details of the experiment; Impact of an access to water; Results which indicate that fur-farmed mink are still motivated to perform the same activities as their wild counterparts
323 citations
TL;DR: Some of the actions that have recently emerged as effective for dealing with this invasive species are presented and which considerations may further encourage competent European authorities to take action to prevent and mitigate impacts of American mink are discussed.
319 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 42 |
| 2024 | 76 |
| 2023 | 131 |
| 2022 | 206 |
| 2021 | 138 |
| 2020 | 82 |