Topic
Microglossa
About: Microglossa is a research topic. Over the lifetime, 15 publications have been published within this topic receiving 128 citations.
Papers
TL;DR: Infusions of S. microglossa presented antiproliferative effect at a highest concentration, which caused a significant reduction in the mitotic index (MI) compared with control in the studied populations.
Abstract: The medicinal specie Solidago microglossa DC., which is native from South America, is used as infusion (tea) for stomach disorders in popular medicine. This study aimed to evaluate the potential cytotoxic effect of these infusions on the cell cycle of Allium cepa. In natura leaves of three populations of this species were used in preparing infusions at two concentrations: 1.75 mg/mL and 14 mg/mL. Onion (Allium cepa) root-tip cells were used as test system in in vivo assays. Slides were done through smashing technique. Cells were analyzed in all cell cycles of A. cepa, totalizing 6000 cells for each group of bulbs. The mitotic index (MI) was calculated, and the statistical analysis was carried out through the Chi-square test (χ2 = 0.05). The results show that the infusions of S. microglossa at a highest concentration (14 mg/mL) caused a significant reduction in the MI compared with control in the studied populations. In concentrations commonly used by people there was a significant increase of MI in relation to controlled populations 1 and 3 and a decrease in population 2. In conclusion, infusions of S. microglossa presented antiproliferative effect at a highest concentration.
35 citations
TL;DR: The antimicrobial activity of the methanol extract from Solidago microglossa roots, essential oil from its aerial part and some isolated compounds was investigated and the oil exhibited concentration-dependent activity against all the tested bacteria and yeasts.
31 citations
TL;DR: Instrumental neutron activation analysis (INAA) has been applied to multielemental determinations of medicinal extracts obtained from the plants and shown a good accuracy and reproducibility of the method.
Abstract: Instrumental neutron activation analysis (INAA) has been applied to multielemental determinations of medicinal extracts obtained from the plants. Cordia Verbenacea DC, Folidago Microglossa DC, and Petiveria Alliacea.
24 citations
TL;DR: This study has reported, for the first time, the in vitro antischistosomal effects of S. microglossa and A. cymbifera extracts, also showing promising compounds against adult schistosomes.
Abstract: Schistosomiasis, caused by helminth flatworms of the genus Schistosoma, is a neglected tropical disease that afflicts over 230 million people worldwide. Currently, treatment is achieved with only one drug, praziquantel (PZQ). In this regard, the roots of Solidago microglossa (Asteraceae) and Aristolochia cymbifera (Aristolochiaceae) are popularly used as anthelmintic. Despite their medicinal use against helminthiasis, such as schistosomiasis, A. cymbifera, and S. microglossa have not been evaluated against S. mansoni. Then, in this work, the in vitro antischistosomal activity of the crude extracts of A. cymbifera (Ac) and S. microglossa (Sm) and their isolated compounds were investigated against S. mansoni adult worms. Sm (200 μg/mL) and Ac (100–200 μg/mL) were lethal to all male and female worms at the 24 h incubation. In addition, Sm (10–50 μg/mL) and Ac (10 μg/mL) caused significant reduction in the parasite’s movements, showing no significant cytotoxicity to Vero cells at the same range of schistosomicidal concentrations. Confocal laser scanning microscopy revealed that Sm and Ac caused tegumental damages and reduced the numbers of tubercles of male schistosomes. Chromatographic fractionation of Sm leads to isolation of bauerenol, α-amirin, and spinasterol, while populifolic acid, cubebin, 2-oxopopulifolic acid methyl ester, and 2-oxopopulifolic acid were isolated from Ac. At concentrations of 25–100 μM, bauerenol, α-amirin, spinasterol, populifolic acid, and cubebin showed significant impact on motor activity of S. mansoni. 2-oxopopulifolic acid methyl ester and 2-oxopopulifolic acid caused 100% mortality and decreased the motor activity of adult schistosomes at 100 μM. This study has reported, for the first time, the in vitro antischistosomal effects of S. microglossa and A. cymbifera extracts, also showing promising compounds against adult schistosomes.
16 citations
TL;DR: The aerial parts of Microglossa zeylanica collected in Sri Lanka contained β-farnesene, squalene, dammadienyl acetate, caryophyllen-1,10-epoxide, 5,4′-dihydroxy-6,7,8,3′-tetramethoxyflavone, dehydrofalcarindiol and two new alicyclic diterpenes, microglossic acid and dihydromicro glossic acid.
15 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2020 | 2 |
| 2015 | 1 |
| 2010 | 1 |
| 2009 | 1 |
| 2008 | 2 |
| 2006 | 1 |