TL;DR: The extrinsic signals controlling each binary lineage decision were defined, enabling us to logically block differentiation toward unwanted fates and rapidly steer pluripotent stem cells toward 80%-99% pure human mesodermal lineages at most branchpoints.
TL;DR: Observations can be interpreted to suggest that nicotinamide plays an important, if not central, role in chicken limb mesoderm differentiation into chondrogenic and myogenic elements, and shifts in concentrations of low molecular weight and essential compounds such as Nicotinamide may be the illusive embryonic inducer(s) which control cellular differentiation.
TL;DR: The adhesive glycoprotein fibronectin (FN), a component of the network of extracellular matrix fibrils on the inner surface of the blastocoel roof (BCR), has been proposed to play a major role in directing mesodermal cell migration during amphibian gastrulation.
TL;DR: It is concluded that primitive mammalian erythropoiesis arises during gastrulation through the ordered temporal expression of tal-1, rbtn2, GATA2, and GATA-1 in a subset of extraembryonic mesoderm cells.
TL;DR: The architecture of regulatory interactions with the spatial restriction of regulatory gene expression is integrated to model the logic control of endoderm development in sea urchin embryos up to mid-blastula stage.