Topic
Macromonomer
About: Macromonomer is a research topic. Over the lifetime, 2957 publications have been published within this topic receiving 53105 citations. The topic is also known as: macromonomers.
Papers published on a yearly basis
Papers
TL;DR: In this article, a tetra-PEG gel was designed by combining two symmetrical tetrahedron-like macromonomers of the same size, which had a homogeneous structure and resultant high mechanical strength comparable to that of native articular cartilage.
Abstract: As a new class of high-strength hydrogels, we designed a tetra-PEG gel by combining two symmetrical tetrahedron-like macromonomers of the same size. Because the nanostructural unit of the gel network was defined by the length of the tetrahedral PEG arm, the gel had a homogeneous structure and resultant high mechanical strength comparable to that of native articular cartilage. Furthermore, since the gel was formed by mixing two biocompatible macromonomer solutions, the gelation reaction itself and the resultant gel were also biocompatible. The breaking strength had local maxima at the overlap concentration of the macromonomers (C*) and at 2C*. Dynamic light scattering measurement indicated the near absence of inhomogeneities in the network at C*. Thus, we successfully designed and fabricated a high-strength hydrogel by controlling the homogeneity of network structure for the first time, which will lead to multiplied effects, i.e., contributing to the understanding of ideal networks, providing a universal s...
1,172 citations
TL;DR: Copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click-to" coupling of a photocleavable doxorubicin (DOX)-alkyne derivative to the azide core was quantitative across a wide range of nanoscopic sizes (∼6-∼50 nm).
Abstract: The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by "graft-through" ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click-to" coupling of a photocleavable doxorubicin (DOX)-alkyne derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6-∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically effective against human cancer cells.
373 citations
TL;DR: Minimal polymerization in the absence of light confers temporal control and alludes to potential application at one of the frontiers of materials chemistry whereby precise spatiotemporal "on/off" control and resolution is desirable.
Abstract: Photoinduced living radical polymerization of acrylates, in the absence of conventional photoinitiators or dye sensitizers, has been realized in “daylight’”and is enhanced upon irradiation with UV radiation (λmax ≈ 360 nm). In the presence of low concentrations of copper(II) bromide and an aliphatic tertiary amine ligand (Me6-Tren; Tren = tris(2-aminoethyl)amine), near-quantitative monomer conversion (>95%) is obtained within 80 min, yielding poly(acrylates) with dispersities as low as 1.05 and excellent end group fidelity (>99%). The versatility of the technique is demonstrated by polymerization of methyl acrylate to a range of chain lengths (DPn = 25–800) and a number of (meth)acrylate monomers, including macromonomer poly(ethylene glycol) methyl ether acrylate (PEGA480), tert-butyl acrylate, and methyl methacrylate, as well as styrene. Moreover, hydroxyl- and vic-diol-functional initiators are compatible with the polymerization conditions, forming α,ω-heterofunctional poly(acrylates) with unparalleled ...
351 citations
TL;DR: In this article, two macromonomers containing ethylene oxide (EO) segments with different degrees of polymerization (DPPEO = 5 and 23), capped by a methoxy and a methacrylate group (PEOMA), were polymerized by ATRP in organic solvents.
Abstract: Two macromonomers containing ethylene oxide (EO) segments with different degrees of polymerization (DPPEO = 5 and 23), capped by a methoxy and a methacrylate group (PEOMA), were polymerized by atom transfer radical polymerization (ATRP) in organic solvents. In addition to the direct preparation of densely grafted brush copolymers by “grafting through” the macromonomers, the lower molecular weight PEOMA (MWav = 300 g/mol, DPPEO = 5) was also employed in a “grafting from” reaction using a well-defined multifunctional macroinitiator poly(2-(2-bromopropionyloxy)ethyl methacrylate) (PBPEM, Mn,app = 82 × 103 g/mol, Mw/Mn = 1.16, degree of polymerization of backbone DPb = 428). This procedure allowed the preparation of densely double-grafted brush copolymers with various degrees of polymerization of the side chains (DPsc = 12−43). Attempts to prepare double-grafted brushes with DPsc > 50 or to use a macromonomer with a longer PEO chain (MWav = 1100 g/mol, DPPEO = 23) in the “grafting from” reaction resulted in f...
327 citations
TL;DR: Densely cross-linked hydrogels with a high DM have been shown to be more mechanically robust while maintaining cytocompability and cell adhesion.
310 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 3 |
| 2024 | 12 |
| 2023 | 20 |
| 2022 | 49 |
| 2021 | 30 |
| 2020 | 57 |