TL;DR: Although much has been published about the pathophysiology and treatment of necrotic spider bites, therapeutic interventions continue without evidence-based justification.
Abstract: Although much has been published about the pathophysiology and treatment of necrotic spider bites, therapeutic interventions continue without evidence-based justification.
TL;DR: Animal model studies suggest the potential value of specific antivenom to decrease lesion size and limit systemic illness even when such administration is delayed.
TL;DR: The authors review an indepth discussion of the spider, venom, diagnosis, clinical presentation, laboratory findings, treatment, and prevention of Brown recluse spider loxoscelism.
Abstract: The Brown recluse spider has emerged into a potent venomous creature. Loxoscelism and necrotic arachnidism is not an infrequent medical problem. Spiders other than L. reclusa are capable of inflicting painful and persisting necrotic wounds, however, management of the local cutaneous lesions are similar. Systemic complications of loxoscelism appear to be characteristic for spiders of the genus loxosceles. The authors review an indepth discussion of the spider, venom, diagnosis, clinical presentation, laboratory findings, treatment, and prevention. The literature on loxoscelism is contradictory because of the individuality of the reaction. Experience with many patients is the only guide to management of these cases.
TL;DR: Long-term outcome after brown recluse spider bite was good, serious complications were rare, as was the need for skin grafting and the development of other complications.
TL;DR: The objective of the present review is to provide insights into the brown spider venoms and loxoscelism based on recent results, including the biology of brown spiders, the clinical features of loxocelism and the diagnosis and therapy of brown spider bites.