Lhasa Apso

Abstract: Lissencephaly, a congenital absence of cerebrocortical convolutions, was discovered in 2 Lhasa Apso dogs by clinical and pathologic evaluation. Neurologic abnormalities, which became evident within the 1st year of life, included behavioral, visual, and convulsive disorders. The neurologic abnormalities were mild or delayed in onset after birth, indicating the dog is less dependent on the cerebral cortex for sensorimotor function than is man.

Abstract: Homozygosity for a large deletion in the solute carrier family 45, member 2 (SLC45A2) gene causes oculocutaneous albinism (OCA) in the Doberman Pinscher breed An albino Lhasa Apso did not have this g27141_31223del (CanFam2) deletion in her SLC45A2 sequence Therefore, SLC45A2 was investigated in this female Lhasa Apso to search for other possible variants that caused her albinism The albino Lhasa Apso was homozygous for a nonsynonymous substitution in the seventh exon, a c1478G>A base change that resulted in a glycine to aspartic acid substitution (pG493D) This mutation was not found in a wolf, a coyote, or any of the 15 other Lhasa Apso dogs or 32 other dogs of breeds related to the Lhasa Apso However, an albino Pekingese, 2 albino Pomeranians, and an albino mixed breed dog that was small and long haired were also homozygous for the 493D allele The colored puppies of the albino Lhasa Apso and the colored dam of the 2 albino Pomeranians were heterozygous for this allele However, an albino Pug was homozygous for the 493G allele and therefore although we suggest the 493D allele causes albinism when homozygous in several small, long haired dog breeds, it does not explain all albinism in dogs A variant effect prediction for the albino Lhasa Apso confirms that pG493D is a deleterious substitution, and a topology prediction for SLC45A2 suggests that the 11th transmembrane domain where the 493rd amino acid was located, has an altered structure

Abstract: The term ganglioneuroma refers to a neoplastic proliferation of ganglion cells and nerve fibers. There are reports of ganglioneuromas in dog~,~JO F344 rats9 and in a young cat.* Ganglioneuromatosis refers to a hyperplastic proliferation of ganglion cells and nerves. In human beings, ganglioneuromatosis of the alimentary tract is characterized by hyperplasia of the autonomic ganglia and nerves.'J This report describes a lesion in the colon of a dog with findings that are consistent with those of ganglioneuromatosis. A 12-month-old, female Lhasa Apso was presented for evaluation of recurring tenesmus, hematochezia, and rectal prolapse of 9 months duration. After several unsuccessful