Topic
Levorotatory
About: Levorotatory is a research topic. Over the lifetime, 191 publications have been published within this topic receiving 1389 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: The levorotatory form of 5-hydroxytryptophan significantly improved the ataxia score and significantly modified the time of standing upright, the spread of feet, the speed of walking, speaking, and writing.
Abstract: • Some features of cerebellar ataxia have been reported to regress partially with long-term administration of 5-hydroxytryptophan or levorotatory form of 5-hydroxytryptophan. To test this effect further, 30 patients with various inherited or acquired cerebellar ataxias underwent a randomized, double-blind trial of placebo, and the levorotatory form of 5-hydroxytryptophan taken orally for four months. The levorotatory form of 5-hydroxytryptophan significantly improved the ataxia score. It also significantly modified the time of standing upright, the spread of feet, the speed of walking, speaking, and writing. In five cases in which the levorotatory form of 5-hydroxytryptophan therapy was maintained for 12 months, the effect continued progressively.
89 citations
Patent•
28 Jan 1987
TL;DR: The levorotatory isomer of benzhydrylsulfinylacetamide has useful pharmaceutical activity on the central nervous system, particularly as an antidepressant and stimulant in the treatment of hypersomnia and Alzheimer's disease as mentioned in this paper.
Abstract: The levorotatory isomer of benzhydrylsulfinylacetamide has useful pharmaceutical activity on the central nervous system, particularly as an antidepressant and stimulant in the treatment of hypersomnia and Alzheimer's disease.
86 citations
TL;DR: Both enantiomers of methyl (E )-2,4,5,tetradecatrienoate were synthesized with 125-127% the rotatory power of the natural product which was isolated as the pheromone of Acanthoscelides obtectus as discussed by the authors.
72 citations
TL;DR: It is demonstrated that the levorotatory form of 5-hydroxytryptophan is able to modify significantly the cerebellar symptoms in patients with Friedreich's ataxia, however, the effect is only partial and not clinically major.
Abstract: Objective: To study the effect of the levorotatory form of 5-hydroxytryptophan on the cerebellar symptoms of Friedreich's ataxia. Design: Cooperative double-blind study of the levorotatory form of 5-hydroxytryptophan vs placebo. Setting: Twelve centers in research hospitals. Patients: Twenty-six patients were included; 19 completed the study (mean±SD age of patients, 25.9±8.1 years). Of these 19 patients, eight were treated with placebo and 11 were treated with the drug. Main Outcome Measures: A semiquantitative scale for kinetic and static ("postural") cerebellar functions and quantitative measurements of time in standard tests that evaluated stance, speech, writing, and drawing. Results: In the active treatment group, a significant decrease of the kinetic score was observed (P=.03), indicating an improvement in coordination. Conclusions: These results demonstrated that the levorotatory form of 5-hydroxytryptophan is able to modify significantly the cerebellar symptoms in patients with Friedreich's ataxia. However, the effect is only partial and not clinically major.
63 citations
Journal Article•
TL;DR: A critical review of the literature shows that the dysphoric and psychotomimetic side effects of sigma opiates reside in the levorotatory and not in the dextrorotatory or (+)-isomer, as currently believed.
50 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2020 | 3 |
| 2019 | 1 |
| 2018 | 6 |
| 2017 | 19 |
| 2016 | 3 |
| 2015 | 1 |