Topic
Labdane
About: Labdane is a research topic. Over the lifetime, 1103 publications have been published within this topic receiving 17150 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: Pharmacological assays have frequently corroborated the traditional uses of Croton species, and a wide diversity of effects having been noticed, including hypolipidemic, hypoglycaemic, anti-oestrogen and anti-cancer.
Abstract: Croton is a genus of Euphorbiaceae comprising around 1,300 species, widespread in tropical regions of the Old and New Worlds. Several species have a long role in the traditional use of medicinal plants in Africa, Asia and South America. Popular uses include treatment of cancer, constipation, diabetes, digestive problems, dysentery, external wounds, fever, hypercholesterolemia, hypertension, inflammation, intestinal worms, malaria, pain, ulcers and weight-loss. Several species of Croton have a red sap, in some species containing proanthocyanidins and/or alkaloids. The latter may be taspine or some of several benzylisoquinoline-like compounds. Diterpenes are very common in Croton, corresponding to clerodanes, cembranoid, halimanes, kauranes, labdanes, phorbol esters, trachylobanes and sarcopetalanes. Some species are aromatic due to the possession of volatile oils. Representatives of new classes of compounds (phenylbutanoids, glutarimide alkaloids, sarcopetalane diterpenes) have been isolated from Croton species. While laticifers have been described in Croton species, so far there are no anatomical studies about secretory structures of volatile oil. Few studies about flavonoids have been carried out with Croton species. Chemical affinities are apparent in the genus, grouping species with (i) kauranes and/or labdanes, (ii) trachylobanes and (iii) alkaloids. Pharmacological assays have frequently corroborated the traditional uses of Croton species. A great part of pharmacological assays with Croton substances dealt with the clerodane trans-dehydrocrotonin, a wide diversity of effects having been noticed, including hypolipidemic, hypoglycaemic, anti-oestrogen and anti-cancer. Cytotoxic effects also have been observed in assays with alkaloids (taspine) and with secokaurene, labdane and cembranoid diterpenes. Several other effects of Croton substances have been registered, including anti-hypertensive, anti-inflammatory, antimalarial, antimicrobial, antispasmodic, antiulcer, antiviral and myorelaxant.
495 citations
262 citations
TL;DR: This review presents all the substances already described in this oleoresin, together with structures and activities of its main terpenoids.
Abstract: Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and diterpenes (labdane, clerodane and kaurane skeletons) are different for each Copaifera species and have been linked to several reported biological activities, ranging from anti-tumoral to embriotoxic effects. This review presents all the substances already described in this oleoresin, together with structures and activities of its main terpenoids.
261 citations
TL;DR: In this article, the authors report about the stimulation of heterologously expressed human bitter taste receptors, hTAS2Rs, by the bitter sesquiterpene lactone herbolide D.
Abstract: Sesquiterpene lactones are a major class of natural bitter compounds occurring in vegetables and culinary herbs as well as in aromatic and medicinal plants, where they often represent the main gustatory and pharmacologically active component. Investigations on sesquiterpene lactones have mainly focused on their bioactive potential rather than on their sensory properties. In the present study, we report about the stimulation of heterologously expressed human bitter taste receptors, hTAS2Rs, by the bitter sesquiterpene lactone herbolide D. A specific response to herbolide D was observed i.a. for hTAS2R46, a so far orphan bitter taste receptor without any known ligand. By further investigation of its agonist pattern, we characterized hTAS2R46 as a bitter receptor broadly tuned to sesquiterpene lactones and to clerodane and labdane diterpenoids as well as to the unrelated bitter substances strychnine and denatonium.
198 citations
TL;DR: In this article, the mass spectra and GC retention times of 19-Norisopimarane and isopimara-9(11), 15-diene-3β, 19-diol were compared with those of the synthetic standards, and the remaining two compounds were tentatively identified as rimuane and as a 17nortetracyclic diterpane on the basis of mass spectral evidence.
186 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 22 |
| 2024 | 22 |
| 2023 | 34 |
| 2022 | 44 |
| 2021 | 21 |
| 2020 | 43 |