Topic
Karyomegaly
About: Karyomegaly is a research topic. Over the lifetime, 30 publications have been published within this topic receiving 536 citations.
Papers
Journal Article•
TL;DR: Renal biopsy revealed an unusually marked karyomegaly particularly of the tubular epithelium and cytopathological changes were associated with chronic interstitial nephritis, suggesting that there is a relationship between these changes.
Abstract: In 3 patients, two 26 and one 29 years of age, a nephropathy was accidentally discovered which progressed to end stage renal failure within 4 to 6 years. Renal biopsy revealed an unusually marked karyomegaly particularly of the tubular epithelium. These cytopathological changes were associated with chronic interstitial nephritis. Biopsies of other organs, i.e. liver, colon, bronchus and lungs indicated in 2 patients a systemic distribution of the karyomegaly, particularly in mesenchymal cells. Neither the chronic interstitial nephritis nor the karyomegaly could be ascribed to a recognized etiology. This suggests, therefore, that there is a relationship between these changes. The karyomegaly could be the result of the action of some antimitotic agent such as chemical toxins or virus infections.
59 citations
1 Jan 1980
TL;DR: S -1-Cyano-2-hydroxy-3,4-epithiobutanes isolated from the seed of Crambe abyssinica showed poor growth and increased serum levels of alkaline phosphatase, total bilirubin and glutamic-oxaloacetic transaminase, and ornithine carbamyl transferase and the severity and occurrence of renal and hepatic lesions were dose-dependent.
Abstract: Absrraet-2S-1-Cyano-2-hYd~oxy-3.4-epithiobutanes (erythro and thl'l!ol isolated from th~ seed .of Crambe abyssinica. were fed to groups of six weanling rats at levels of O. 75. 150 or 300 ppm In the ~Iet for 9{) days. The higher dose groups showed poor growth and incr~ seru~ levels o~ alkaline phosphatase. total bilirubin. gJutamic-oxaloacetic transaminase. gJutamlc-pyru~lc t~sammase and ornithine carbamyl transferase. The severity and occurrence ~f renal and hepatl~ lesIons ~ere dose: dependent Renal alterations consisted .of hYl'l7rtro!'hy of proxImal t~buJar epIthelial cells WIth .p~oml nent karyomegaly. Hepatic lesions consIsted pnIl?anly o.f mega.locytosls of the hepatocyt~ and bile duct hyperplasia with disruption of the normal hepatic architecture. Half of the rats In the hlgh.dose group had karyomegaly of pancreatic acinar cells.
53 citations
TL;DR: In this paper, S -1-Cyano-2-hydroxy-3,4-epithiobutanes (erythro and threo) isolated from the seed of Crambe abyssinica, were fed to groups of six weanling rats at levels of 0, 75, 150 or 300 ppm in the diet for 90 days.
53 citations
TL;DR: Four additional cases as well as two family investigations support the association of karyomegaly and interstitial nephritis as a distinct entity and the finding of the same HLA haplotype, A9/B35, in four of six HLA-typed cases suggests the possibility of a genetic defect on chromosome 6, which is inherited and linked to the HLA locus.
49 citations
TL;DR: Heavy metal nephropathy is a pathologic entity of the renal tubular epithelium of rats, evoked by lead, gold, and other heavy metals.
Abstract: Heavy metal nephropathy is a pathologic entity of the renal tubular epithelium of rats, evoked by lead, gold, and other heavy metals. It is characterized acutely by coagulative necrosis, subacutely by cortical fibrosis, and chronically by cytomegaly and karyomegaly. Finally, adenomas develop, some of which become malignant.
43 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 3 |
| 2020 | 1 |
| 2018 | 1 |
| 2016 | 1 |
| 2014 | 3 |
| 2013 | 3 |