TL;DR: The Musculoskeletal System: Anatomical Overview and Structural Analysis of MusculOSkeltal Systems: Advanced Topics is presented, which describes the structure and function of the body's connective tissue, as well as some of the issues and complications related to these systems.
Abstract: 1. The Musculoskeletal System 1.1. Anatomical Overview 1.2. The Functions of the Musculoskeletal System 1.3. Bones 1.4. Joints of the Body 1.5. Soft Tissue Structures 1.6. The Hip, Knee, and Spine 1.7. Damage and Repair 1.8. Summary 1.9. Exercises 2. Loads and Motion in the Musculoskeletal System 2.1. Basic Concepts 2.2. Static Analysis of Skeletal System 2.3. The Musculoskeletal Dynamics Problem 2.4. Joint Stability 2.5. Summary 2.6. Exercises 3. Tissue Mechanics I: Bone 3.1. Introduction 3.2. Composition of Bone 3.3. Bone as a Hierarchical Composite Material 3.4. Elastic Anisotropy 3.5. Material Properties of Cortical Bone 3.6. Material Properties of Trabecular Bone 3.7. Hierarchical Analysis 3.8. Structural Anisotropy 3.9. Biomechanics of Bone Adaptation 3.10. Summary 3.11. Exercises 4. Tissue Mechanics II: Soft Tissue 4.1. Tendon and Ligament 4.2. Articular Cartilage 4.3. Intervertebral Disc 4.4. Muscle 4.5. Viscoelasticity 4.6. Summary 4.7. Exercises 5. Structural Analysis of Musculoskeltal Systems: Beam Theory 5.1. Basic Concepts 5.2. Symmetric Beams 5.3. Unsymmetrical Beams 5.4. Case Studies: Whole Bone Mechanics 5.5. Summary 5.6. Exercises 6. Structural Analysis of Musculoskeltal Systems: Advanced Topics 6.1. Beams on Elastic Foundation 6.2. Torsion of Noncircular Sections 6.3. Contact Stress Analysis 6.4. Summary 6.5. Exercises 7. Bone-Implant Systems 7.1. Implant Materials 7.2. Fracture Fixation Devices 7.3. Joint Replacements 7.4. Design of Bone-Implant Systems 7.5. Summary 7.6. Exercises 8. Fracture Fixation Devices 8.1. Fracture Repair 8.2. Mechanics of Intramedullary Rods 8.3. Combined Behavior of Bone and Rod 8.4. Mechanics of Bone Plates 8.5. Combined Behavior of Bone and Plate 8.6. Plate Fixation: Other Considerations 8.7. Irregular Bone Cross Section with a Plate 8.8. External Fixators 8.9. Controlling Callus Strains 8.10. Bone Screws and Effects of Holes 8.11. Other Issues and Complications 8.12. Summary 8.13. Exercises 9. Total Hip Replacements 9.1. Function: Kinematics and Loads 9.2. Fixation: Femoral Stems 9.3. Stresses in the Central Zone 9.4. BOEF and FEA Models for Bone-Stem Systems 9.5. Summary 9.6. Exercises 10. Total Knee Replacements 10.1. Knee Function 10.2. Knee Structure 10.3. Knee Replacements 10.4. Summary 10.5. Exercises 11. Articulating Surfaces 11.1. Damage Modes 11.2. Design: General Considerations 11.3. Summary 11.4. Exercises Suggestions for Further Reading Index
TL;DR: These radiologic changes may help distinguish ELSTs from other tumors of the temporal bone and posterior fossa.
Abstract: PURPOSE: To evaluate the radiologic appearance of endolymphatic sac tumors (ELSTs). MATERIALS AND METHODS: Four patients with ELST underwent computed tomography (CT), and two of the four also underwent magnetic resonance (MR) imaging. Their radiologic studies were reviewed for characteristic findings of ELST. RESULTS: Retrolabyrinthine bone destruction was centered at the external aperture of the vestibular aqueduct in all four patients. CT showed irregular bone margins and prominent intratumoral bone in all four patients. At MR imaging, one tumor was almost homogeneous and isointense to gray matter with T1 weighting, and the other was heterogeneous and contained hyper-, hypo-, and isointense foci with T1 and T2 weighting. CONCLUSION: These radiologic changes may help distinguish ELSTs from other tumors of the temporal bone and posterior fossa.
TL;DR: This study shows a facile method to clinically treat bone defects of irregular shapes by incorporating black phosphorus nanosheets and osteogenic peptide into β-tricalcium phosphate/poly(lactic acid-co-trimethylene carbonate) (TCP/P(DLLA-TMC)) nanocomposite scaffolds.
Abstract: While scaffold-based tissue engineering has been widely used to treat bone critical-size defects, challenges such as implantation of scaffolds in defects with irregular shapes and implantation of scaffolds through minimally invasive surgery remain in the tissue engineering field. Customized bioactive bone tissue engineering scaffolds with reconfigurable capability for both easy scaffold implantation and perfect shape fitting in irregularly shaped bone defects are therefore needed. Herein, applying 4D printing, photothermal-responsive shape memory bone tissue engineering scaffolds are constructed by incorporating black phosphorus nanosheets and osteogenic peptide into β-tricalcium phosphate/poly(lactic acid-co-trimethylene carbonate) (TCP/P(DLLA-TMC)) nanocomposite scaffolds. When near-infrared irradiation is applied to customized scaffolds on-demand, scaffold temperature rapidly increases to 45 °C, enabling scaffold shape reconfiguration for easy scaffold implantation and precise fitting in irregular bone defects. Once the implantation is finished, scaffold temperature rapidly decreases to 37 °C and scaffolds display mechanical properties comparable to those of human cancellous bone. The improved osteogenesis in bone defect sites is then initiated through pulsed peptide release from scaffolds. Compact integration of reconfigurable scaffolds in rat cranial bone defects and improved new bone formation are demonstrated through micro-computed tomography and histochemical analyses. This study shows a facile method to clinically treat bone defects of irregular shapes.
TL;DR: When available and when the patient will accommodate the equipment, computed tomography may give a definitive diagnosis owing to its superior resolution and differentiation of soft tissue structures.
Abstract: Due to the complex nature of the anatomy of the equine head, superimposition of numerous structures, and poor soft tissue differentiation, radiography may be of limited value in the diagnosis of basilar skull fractures. However, in many horses radiographic changes such as soft tissue opacification of the guttural pouch region, irregular bone margination at the sphenooccipital line, attenuation of the nasopharynx, ventral displacement of the dorsal pharyngeal wall and the presence of irregularly shaped bone fragments in the region of the guttural pouches are suggestive of a fracture of the skull base. These findings in conjunction with physical examination findings and historical information may lead to a presumptive diagnosis of a fracture. When available and when the patient will accommodate the equipment, computed tomography may give a definitive diagnosis owing to its superior resolution and differentiation of soft tissue structures.
TL;DR: High-resolution sonography of the ribs is a useful method of characterizing rib lesions in patients who have hot-uptake lesions on bone scintigraphy, and is compared between the groups with fracture and metastasis.
Abstract: OBJECTIVE. Our aim was to evaluate whether high-resolution sonography can provide additional information concerning rib lesions compared with radiography or bone scintigraphy. MATERIALS AND METHODS. Fifty-eight patients with high-uptake rib lesions seen on bone scintigraphy were selected. Radiography and rib high-resolution sonography were performed on these patients. High-resolution sonography was performed using a linear 5–12 MHz transducer. By means of clinical history, histopathologic examination, and follow-up observation, these patients were classified into rib fracture (n = 37), rib metastasis (n = 18), or unknown (n = 3) groups. High-resolution sonography images of the 55 proven cases were reviewed for the presence of five representative findings: cortical disruption, callus formation, cortical deformity, mass, or bone destruction. The frequencies of these findings were compared between the groups with fracture and metastasis. RESULTS. Rib lesions were matched by bone scintigraphy and high-resolution sonography in 53 (96%) of 55 patients and by bone scintigraphy and plain radiography in 23 (42%) of 55 patients. High-resolution sonography revealed 17 (94%) of 18 patients with metastasis and 36 (97%) of 37 patients with rib fractures. Metastatic lesions were seen as mass formation (n = 13) and irregular bone destruction (n = 7) on high-resolution sonography. Fracture was seen as cortical disruption with or without hematoma (n = 17), callus formation (n = 9), or cortical deformity, such as angling or stepping (n = 12). CONCLUSION. High-resolution sonography of the ribs is a useful method of characterizing rib lesions in patients who have hot-uptake lesions on bone scintigraphy.