Topic
Iridoid
About: Iridoid is a research topic. Over the lifetime, 1601 publications have been published within this topic receiving 31952 citations. The topic is also known as: iridoids & iridoid monoterpenoid.
Papers published on a yearly basis
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Papers
TL;DR: expression of the eight genes encoding this pathway, together with two genes boosting precursor formation and two downstream alkaloid biosynthesis genes, in an alternative plant host allows the heterologous production of the complex MIA strictosidine, which confirms the functionality of all enzymes of the pathway and highlights their utility for synthetic biology programmes.
Abstract: The (seco)iridoids and their derivatives, the monoterpenoid indole alkaloids (MIAs), form two large families of plant-derived bioactive compounds with a wide spectrum of high-value pharmacological and insect-repellent activities. Vinblastine and vincristine, MIAs used as anticancer drugs, are produced by Catharanthus roseus in extremely low levels, leading to high market prices and poor availability. Their biotechnological production is hampered by the fragmentary knowledge of their biosynthesis. Here we report the discovery of the last four missing steps of the (seco)iridoid biosynthesis pathway. Expression of the eight genes encoding this pathway, together with two genes boosting precursor formation and two downstream alkaloid biosynthesis genes, in an alternative plant host, allows the heterologous production of the complex MIA strictosidine. This confirms the functionality of all enzymes of the pathway and highlights their utility for synthetic biology programmes towards a sustainable biotechnological production of valuable (seco)iridoids and alkaloids with pharmaceutical and agricultural applications.
470 citations
TL;DR: Iridoid structures published for the first time during 1980-1989 are listed with available physical and spectral data: mp, [α]D, UV, 1 H nmr, 13 C nmr.
Abstract: Iridoid structures published for the first time during 1980-1989 are listed with available physical and spectral data: mp, [α]D, UV, 1 H nmr, 13 C nmr. Also included are revisions of iridoid structures originally published prior to 1980. The compounds are indexed alphabetically and by molecular weight, and a plant source index is also included
296 citations
TL;DR: The tested compounds, which possess immunostimulating activities, may contribute to the traditional claims of Plantago-based natural products used in treating cancers and infectious diseases.
Abstract: A number of Plantago spp especially P major has long been used in the treatment of diseases such as infection, inflammation and cancer In this study, we evaluated the immunomodulatory activities of five chemical classes of pure compounds obtained from the Plantago genus on human peripheral blood mononuclear cells (PBMC) Studies were conducted on lymphocyte transformation by BrdU immunoassay and secretion of interferon-gamma (IFN-gamma) using an ELISA assay Results showed that the water-soluble compounds, namely aucubin, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid, enhanced the activity of human lymphocyte proliferation and secretion of IFN-gamma Among the water-insoluble compounds, with the exception of luteolin, both baicalein and baicalin showed an enhancement of the human PBMC Although oleanolic acid and ursolic acid of the triterpenoids did not significantly affect the proliferation of PBMC, they exhibited a strong stimulation of IFN-gamma secretion Linalool, a monoterpenoid, showed a similar immunomodulatory activity as the triterpenoids The present study concludes that the tested compounds, which possess immunostimulating activities, may contribute to the traditional claims of Plantago-based natural products used in treating cancers and infectious diseases
257 citations
TL;DR: A compilation of new naturally occurring iridoid glycosides, iridoids aglycones, Iridoid derivatives and bis-iridoids reported during 1994-2005 is provided with available physical and spectral data.
Abstract: A compilation of new naturally occurring iridoid glycosides, iridoid aglycones, iridoid derivatives and bis-iridoids reported during 1994-2005 is provided with available physical and spectral data: mp, [alpha]D, UV, IR, 1H- and 13C-NMR as well as natural source with family and references. 418 compounds with 202 references are cited.
245 citations
238 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 15 |
| 2024 | 30 |
| 2023 | 30 |
| 2022 | 70 |
| 2021 | 30 |
| 2020 | 44 |