Topic
Ioxilan
About: Ioxilan is a research topic. Over the lifetime, 42 publications have been published within this topic receiving 486 citations. The topic is also known as: Oxilan-350 & Oxilan.
Papers
TL;DR: In this article, a surface-enhanced laser desorption/ionization (SELDI) ProteinChip array-time of flight mass spectrometry was used for protein profiling of urine and to exemplify its use for a group of patients receiving radiocontrast medium.
Abstract: . Previous attempts to use urinary protein profiles for diagnostic purposes have been rather disappointing with respect to their clinical validity, in part because of the insufficient reproducibility, sensitivity, and rapidity of available techniques. Therefore, a newly developed, high-throughput technique, namely surface-enhanced laser desorption/ionization (SELDI) ProteinChip array-time of flight mass spectrometry, was studied, to assess its applicability for protein profiling of urine and to exemplify its use for a group of patients receiving radiocontrast medium. Assessment of the accuracy, sensitivity, and reproducibility of SELDI in test urinary protein profiling was performed. Renal function was studied in 20 male Sprague-Dawley rats before and after intravenous administration of either 1.25 g/kg ioxilan ( n = 10) or hypertonic saline solution ( n = 10) as a control. Urine samples from 25 patients undergoing cardiac catheterization were obtained before, immediately after, and 6 to 12 h after the procedure. Administration of ioxilan to rats resulted in changes in the abundance of proteins of 9.9, 18.7, 21.0, and 66.3 kD. For patients, even in uncomplicated cases of radiocontrast medium infusion during cardiac catheterization, perturbations in the protein composition occurred but returned to baseline values after 6 to 12 h. Proteins with molecular masses of 9.75, 11.75, 23.5, and 66.4 kD changed in abundance. For patients with impaired renal function, these changes were not reversible within 6 to 12 h. As a proof of principle, one of the peaks, i.e. , that at 11.75 kD, was identified as β 2 -microglobulin. SELDI is a promising tool for the detection, identification, and characterization of trace amounts of proteins in urine. Even for patients without renal complications, proteins with a broad range of molecular masses either appear in or disappear from the urine. Some of these might represent markers of impending nephropathy.
115 citations
TL;DR: Results of the pooled analysis of nonionic contrast agents showed a similar incidence of CIN after iodixanol and iopamidol in patients with preexisting Chronic renal insufficiency (CRI), while both agent showed a significantly lower incidence ofCIN compared to iohexol.
Abstract: Contrast-induced nephropathy (CIN) is associated with high morbidity and mortality. The recent literature contains numerous clinical trials with similar design, endpoints, and patient populations, describing the nephrotoxic effects of various contrast agents, which are higher with ionic vs. nonionic contrast agents. The difference in the incidence of CIN with nonionic contrast agents may be due to the number of benzene rings (monomer vs. dimer), iodine content, osmolality, and viscosity of the individual contrast agents. We evaluated the recently published data from clinical studies with nonionic iodinated contrast agents in patients with preexisting chronic renal insufficiency (CRI) and report the results of pooled analysis of data from recent prospective independent studies of CIN with various nonionic contrast agents. Review of the recent literature revealed that the CIN incidence varies across the studies reviewed and the contrast agents used. The highest incidence of CIN was observed in studies using iohexol or ioxilan. Results of the pooled analysis of nonionic contrast agents (with more than one randomized study) showed a similar incidence of CIN after iodixanol and iopamidol in patients with preexisting CRI, while both agents showed a significantly lower incidence of CIN compared to iohexol. Since iodixanol is more expensive than iopamidol, this observation may be clinically relevant.
71 citations
TL;DR: In this unselected population undergoing PCI, CIN ranged in frequency from 3.3% to 10.5% depending on the definition used and was not associated with in-hospital mortality or substantial morbidity, such as dialysis, and the need for a standardized, clinically relevant definition is underscored.
Abstract: Several definitions have been used to assess rates of contrast-induced nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI). Whether the definition influences observed rates of CIN is unclear. The Oxilan Registry was the first-ever prospective analysis of the efficacy and safety of ioxilan (low-osmolar and low-viscosity contrast medium), including rates of CIN assessed by multiple definitions, in PCI. From July 2006 to June 2007, consecutive patients undergoing PCI using ioxilan were enrolled. Serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) were assessed at baseline and 3 to 5 days after PCI. CIN was defined as SCr increase ≥0.5 mg/dl, eGFR decrease ≥25%, SCr increase ≥25%, or the composite. Of 400 patients (age 62 ± 11 years), 19% were women, 37% were diabetic, 22% were anemic, and 8% had a history of congestive heart failure. Baseline SCr was 1.12 ± 0.3 mg/dl and 24% had an eGFR
63 citations
TL;DR: It is concluded that both high osmolar ionic and low Osmolar non-ionic contrast media may cause temporary glomerular and tubular dysfunction in rats and the kidney is affected most by diatrizoate, less by iohexol, and least by ioxilan.
Abstract: Effects of intravenous ioxilan, a new third generation non-ionic contrast medium, diatrizoate, iohexol and saline on urine profiles were compared. Albumin, glucose, sodium, phosphate, and the enzymes NAG, LDH and GGT were followed in 24 normal rats over 7 days. Diatrizoate significantly affected all profile components during the first two hours. Albuminuria was significantly greater after diatrizoate than after iohexol or ioxilan, and excretion of glucose, LDH and GGT was significantly higher than after ioxilan. Both iohexol and ioxilan increased the excretion of albumin, LDH and GGT, while iohexol also significantly increased excretion of glucose and sodium. There was a greater excretion of glucose and GGT after iohexol than after ioxilan. Saline did not induce any changes. At day 7, serum sodium, urea, creatinine, and albumin were normal for all test substances, and kidney histology revealed no difference between the groups of animals. It is thus concluded that both high osmolar ionic and low osmolar no...
26 citations
TL;DR: Testing whether the biodistribution of IXC particles would be affected by the characteristics of particles found that microparticles are a preferred macrophage imaging agent suggested their potential use as a blood-pool imaging agent.
18 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2017 | 1 |
| 2016 | 1 |
| 2012 | 3 |
| 2010 | 1 |
| 2009 | 1 |
| 2008 | 1 |